Results 201 to 210 of about 173,508 (267)

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Cell Type-Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory. [PDF]

J Neurochem
Huang Z, Mahmood N, Wiebe S, Khoutorsky A, Lacaille JC, Sonenberg N.   +5 more
europepmc   +1 more source

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, EarlyView.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source

Synaptic Plasticity Fragility Underlies a Microglial Pruning Continuum in Major Depressive Disorder and Amyotrophic Lateral Sclerosis. [PDF]

Cureus
Cheung N.
europepmc   +1 more source

Hierarchical Multi‐Mode Computing in Interlayer‐Coupled 3D RRAM Crossbar Arrays

Advanced Science, EarlyView.
2‐deck RRAM crossbar array provides a versatile hardware platform for multifunctional in‐memory computing. Stacked, series, and entropy node configurations enable multi‐layer conductance modulation, logic‐in‐memory operation, genetic learning, and reconfigurable physical unclonable functions.
Seungman Park, Jaewoo Choi, Gigon Nam, Junsu Yu, Donghyun Ryu, Jung‐Kyu Lee, Sungjoon Kim, Sungjun Kim   +7 more
wiley   +1 more source

A data-driven framework for modeling the dendritic spine continuum using dimensionality reduction and clustering toward understanding synaptic plasticity. [PDF]

PLoS One
Sharma US, LeDuc PR, Zhang YJ.
europepmc   +1 more source

Effects of GABAAR modulators CL218872 and MRK-016 on neural repair and synaptic plasticity in mice with Intracerebral hemorrhage. [PDF]

PLoS One
Chen T, He H, Huang F, Liu J, Zhou H, Xu L.   +5 more
europepmc   +1 more source

Molecular sabotage of hippocampal synaptic plasticity by amyloid-β in Alzheimer's disease: A narrative review. [PDF]

J Alzheimers Dis Rep
Behroozi Z, Askarpour H, Baghcheghi Y.
europepmc   +1 more source

Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input. [PDF]

J Neurosci
Holla MR, Brown ST, Raman IM.
europepmc   +1 more source

Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality. [PDF]

iScience
Estarellas C, Álvarez-Salvado E, Pérez-Cervera L, Caramés JM, Pérez-Montoyo E, López-Madrona VJ, Garcia-Hernandez R, Mirasso CR, Canals S.   +8 more
europepmc   +1 more source