Results 91 to 100 of about 6,353,452 (269)

Programming for Meiotic Competence in Mouse Male Germ Cells is Established at the Perinatal Precursor Stage of Development

Molecular Reproduction and Development, Volume 92, Issue 5, May 2025.
ABSTRACT Meiosis is a fundamental aspect of gametogenesis, but how and when the programming is established in germ cells during development is unknown. In the mammalian male germline, mitotic differentiating spermatogonia with the competence for meiotic divisions arise from an undifferentiated pool of spermatogonia that are descended from ...
Qi‐En Yang, Mingyao Yang, Melissa J. Oatley, Jon M. Oatley   +3 more
wiley   +1 more source

Repair of exogenous DNA double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse meiocytes, and is altered in the absence of HORMAD1 [PDF]

, 2018
Repair of SPO11-dependent DNA double-strand breaks (DSBs) via homologous recombination (HR) is essential for stable homologous chromosome pairing and synapsis during meiotic prophase. Here, we induced radiation-induced DSBs to study meiotic recombination
Baarends, W.M. (Willy), Cappellen, W.A. (Gert) van, Carofiglio, F. (Fabrizia), Grootegoed, J.A. (Anton), Inagaki, A. (Akiko), Sleddens-Linkels, E. (Esther), Toth, A. (Attila), Wassenaar, E. (Evelyne)   +7 more
core   +2 more sources

Synaptonemal Complex Central Region Proteins Promote Localization of Pro-crossover Factors to Recombination Events During Caenorhabditis elegans Meiosis

Genetics, 2019
Errors during meiosis are the leading cause of birth defects and miscarriages in humans. Thus, the coordinated control of meiotic events is critical for the faithful inheritance of the genome with each generation...
Cori K. Cahoon, Jacquellyn M Helm, Diana E. Libuda   +2 more
semanticscholar   +1 more source

New method for visualization of C-heterochromatin in synaptonemal complex spreads

Comparative Cytogenetics, 2013
DAPI staining of the metaphase chromosomes pretreated with barium hydroxide generates a C-like banding pattern. In this work a protocol for visualizing similar pattern at the synaptonemal complex (SC) spreads after immunostaining is suggested.
Artem Lisachov
doaj   +1 more source

Molecular structure of human synaptonemal complex protein SYCE1

Chromosoma, 2019
The reduction in chromosome number during meiosis is essential for the production of haploid germ cells and thereby fertility. To achieve this, homologous chromosomes are first synapsed together by a protein assembly, the synaptonemal complex (SC), which
O. Dunne, O. Davies
semanticscholar   +1 more source

Synaptonemal complex antigen location and conservation. [PDF]

The Journal of cell biology, 1987
The axial cores of chromosomes in the meiotic prophase nuclei of most sexually reproducing organisms play a pivotal role in the arrangement of chromatin, in the synapsis of homologous chromosomes, in the process of genetic recombination, and in the disjunction of chromosomes.
A.J.J. Dietrich, W. van Raamsdonk, Q Chen, Peter B. Moens, Christa Heyting   +4 more
openaire   +3 more sources

Identification and Characterization of Novel FSHR Copy Number Variations Causing Premature Ovarian Insufficiency

American Journal of Medical Genetics Part A, Volume 197, Issue 3, March 2025.
ABSTRACT Follicle stimulating hormone (FSH) is a key pituitary gonadotropic hormone implicated in human fertility and is crucial for folliculogenesis and recruitment of new antral follicles. Variations in its receptor, FSHR, can lead to diverse reproductive phenotypes including ovarian hyperstimulation syndrome (OHSS) and premature ovarian ...
Anna Lokchine, Anne Bergougnoux, Nadège Servant, Linda Akloul, Erika Launay, Laura Mary, Laurence Cluzeau, Mathieu Philippe, Mathilde Domin‐Bernhard, Solène Duros, Sylvie Odent, Elena Tucker, Françoise Paris, Marc‐Antoine Belaud‐Rotureau, Sylvie Jaillard   +14 more
wiley   +1 more source

Structural analysis of the human SYCE2–TEX12 complex provides molecular insights into synaptonemal complex assembly [PDF]

Open Biology, 2012
The successful completion of meiosis is essential for all sexually reproducing organisms. The synaptonemal complex (SC) is a large proteinaceous structure that holds together homologous chromosomes during meiosis, providing the structural framework for ...
Owen R. Davies, Joseph D. Maman, Luca Pellegrini   +2 more
doaj   +1 more source

A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae. [PDF]

, 2016
Errors segregating homologous chromosomes during meiosis result in aneuploid gametes and are the largest contributing factor to birth defects and spontaneous abortions in humans.
Burgess, Sean M, Chu, Daniel B
core   +3 more sources

Meiotic crossovers revealed by differential visualization of homologous chromosomes using enhanced haplotype oligo‐painting in cucumber

Plant Biotechnology Journal, Volume 23, Issue 3, Page 887-899, March 2025.
Summary The interaction dynamics of homologous chromosomes during meiosis, such as recognition, pairing, synapsis, recombination, and segregation are vital for species fertility and genetic diversity within populations. Meiotic crossover (CO), a prominent feature of meiosis, ensures the faithful segregation of homologous chromosomes and enriches ...
Qinzheng Zhao, Zhenhui Xiong, Chunyan Cheng, Yuhui Wang, Xianbo Feng, Xiaqing Yu, Qunfeng Lou, Jinfeng Chen   +7 more
wiley   +1 more source