Results 1 to 10 of about 10,153 (109)

Mad1’s ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans

PLoS Genetics, 2021
Meiotic homolog synapsis is essential to ensure accurate segregation of chromosomes during meiosis. In C. elegans, proper regulation of synapsis and a checkpoint that monitors synapsis relies on the spindle checkpoint components, Mad1 and Mad2, and ...
Alice Dévigne, Needhi Bhalla
exaly   +2 more sources

DNA end configurations dictate synaptic complex formation during NHEJ-mediated end bridging [PDF]

Nature Communications
Synapsis, the physical bridging of two broken DNA ends, is a critical step in non-homologous DNA end joining (NHEJ), the primary pathway for repairing DNA double-strand breaks (DSBs) in vertebrates.
Chenyang Zhang, Weiwei Jin, Yuhao Jiang, Weilin Li, Rongguo Fu, Keyin Qi, Wantao Li, Chao Zhao, Di Liu, Bailin Zhao   +9 more
doaj   +2 more sources

All Paired Up with No Place to Go: Pairing, Synapsis, and DSB Formation in a Balancer Heterozygote [PDF]

PLoS Genetics, 2005
The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog.
Kim S Mckim, R Scott Hawley
exaly   +3 more sources

Epigenetic Dysregulation of Mammalian Male Meiosis Caused by Interference of Recombination and Synapsis

Cells, 2021
Meiosis involves a series of specific chromosome events, namely homologous synapsis, recombination, and segregation. Disruption of either recombination or synapsis in mammals results in the interruption of meiosis progression during the first meiotic ...
Roberto De La Fuente, Florencia Pratto, Abrahan Hernández-Hernández   +2 more
exaly   +3 more sources

Somatic Kitl promotes mTOR to facilitate prophase I of meiosis in female embryonic gonads [PDF]

Cell Death and Disease
Homologous synapsis and recombination are the central events that take place in the prophase I of meiosis. Signaling that promotes the germ cell differentiation and prophase I remains elusive.
Chang Liu, Ziyi Jin, Jiyu Chen, Jie Li, Guofeng Feng, Guoxing Yin, Yongqin Yu, Xiaoying Ye, Haowei Sun, Hua Zhang, Fei Gao, Lin Liu   +11 more
doaj   +2 more sources

Accumulation of ph1 (zip4-5B) and ph2 (msh7-3D) mutations fails to boost homoeologous recombination in hexaploid wheat [PDF]

Frontiers in Plant Science
Diversification of the hexaploid (bread) wheat genetic pool using wild genetic resources relies on effective meiotic recombination (crossover) between wheat chromosomes and their counterparts from related species (homoeologues).
Camille Haquet, Isabelle Nadaud, Azahara C. Martin, Azahara C. Martin, Maria-Dolores Rey, Maria-Dolores Rey, Asma Ben Bouslah, Carus John-Bejai, Graham Moore, Pierre Sourdille   +9 more
doaj   +2 more sources

Dynamics of Rye Chromosome 1R Regions with High or Low Crossover Frequency in Homology Search and Synapsis Development [PDF]

PLoS ONE, 2012
In many organisms, homologous pairing and synapsis depend on the meiotic recombination machinery that repairs double-strand DNA breaks (DSBs) produced at the onset of meiosis.
Nohelia T Valenzuela, Tomáš Naranjo
exaly   +2 more sources

Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization [PDF]

The EMBO Journal
In mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown.
Dongteng Liu, Yuxiang Zhang, Dongliang Li, Binjie Jiang, Xudong Zhao, Yanyan Li, Zexiong Lin, Yu Zhao, Zhe Hu, Shuzi Deng, Zheng Li, Haonan Lu, Karen K L Chan, William S B Yeung, Philipp Kaldis, Chencheng Yao, Hengbin Wang, Louise T Chow, Kui Liu   +18 more
doaj   +2 more sources

Meiotic Cohesin SMC1β Provides Prophase I Centromeric Cohesion and Is Required for Multiple Synapsis-Associated Functions

PLoS Genetics, 2013
Cohesin subunit SMC1β is specific and essential for meiosis. Previous studies showed functions of SMC1β in determining the axis-loop structure of synaptonemal complexes (SCs), in providing sister chromatid cohesion (SCC) in metaphase I and thereafter, in
Julian Lange, Michael Seifert, Andreas Beyer   +2 more
exaly   +3 more sources

Failure of homologous synapsis and sex-specific reproduction problems

Frontiers in Genetics, 2012
The prophase of meiosis I ensures the correct segregation of chromosomes to each daughter cell. This includes the pairing, synapsis and recombination of homologous chromosomes. A subset of chromosomal abnormalities, including translocation and inversion,
Hiroki Kurahashi, Hiroshi Kogo, Makiko Tsutsumi   +2 more
exaly   +3 more sources