A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]
, 2015 Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Barchi, Marco +9 more
core +12 more sources
Transcriptomic profile of epileptic children treated with ketogenic therapies [PDF]
Journal of Integrative Neuroscience, 2022 Background: Ketogenic dietary therapies (KDT) are used as a treatment in childhood epilepsy. However, their mechanism has not yet been established. The main objective of this study was to determine the changes in the transcriptomic profile induced by ...
Jana Ruiz-Herrero +8 more
doaj +1 more source
The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
Frontiers in Cell and Developmental Biology, 2022 In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive and nonfunctional synapses and
I. Suárez-Pereira +15 more
doaj +1 more source
HIM-8 Binds to the X Chromosome Pairing Center and Mediates Chromosome-Specific Meiotic Synapsis [PDF]
Cell, 2005 Carolyn M Phillips +2 more
exaly +2 more sources
PLoS Genetics, 2021 Meiotic homolog synapsis is essential to ensure accurate segregation of chromosomes during meiosis. In C. elegans, proper regulation of synapsis and a checkpoint that monitors synapsis relies on the spindle checkpoint components, Mad1 and Mad2, and ...
Alice Devigne, Needhi Bhalla
doaj +1 more source
Evidence that masking of synapsis imperfections counterbalances quality control to promote efficient meiosis. [PDF]
PLoS Genetics, 2013 Reduction in ploidy to generate haploid gametes during sexual reproduction is accomplished by the specialized cell division program of meiosis. Pairing between homologous chromosomes and assembly of the synaptonemal complex at their interface (synapsis ...
Susanna Mlynarczyk-Evans +2 more
doaj +1 more source
Regulation of microglia phagocytosis and potential involvement of exercise
Frontiers in Cellular Neuroscience, 2022 Microglia are considered the main phagocytic cells in the central nervous system, remodeling neural circuits by pruning synapses during development. Microglial phagocytosis is also a crucial process in maintaining adult brain homeostasis and clearing ...
Congqin Li +10 more
doaj +1 more source
The Formation of Bivalents and the Control of Plant Meiotic Recombination
Frontiers in Plant Science, 2021 During the first meiotic division, the segregation of homologous chromosomes depends on the physical association of the recombined homologous DNA molecules.
Yared Gutiérrez Pinzón +3 more
doaj +1 more source
Frontiers in Plant Science, 2023 During meiosis, the chromosome axes and synaptonemal complex mediate chromosome pairing and homologous recombination to maintain genomic stability and accurate chromosome segregation.
Chiara Di Dio +3 more
doaj +1 more source
Chromosome Sites Play Dual Roles to Establish Homologous Synapsis during Meiosis in C. elegans [PDF]
Cell, 2005 Amy J Macqueen +2 more
exaly +2 more sources