Results 61 to 70 of about 60,225 (279)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Analysis of sub‐synchronous resonance between DC‐side dynamics of large‐scale PV plants and nearby synchronous generators shaft

IET Generation, Transmission & Distribution, 2023
This paper investigates the dynamic interactions between large‐scale PV plants and nearby synchronous generators. To this end, a comprehensive model of a PV plant, including the PV arrays characteristic and their voltage controller, DC/DC converter, DC ...
Mohammad Pourheydari, Mostafa Parniani, Mohammad Hasan Ravanji   +2 more
doaj   +1 more source

Dynamics and stability of wind turbine generators [PDF]

, 1981
Synchronous and induction generators are considered. A comparison is made between wind turbines, steam, and hydro units. The unusual phenomena associated with wind turbines are emphasized.
Hinrichsen, E. N., Nolan, P. J.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Pre Synchronization Control Strategy of Virtual Synchronous Generator (VSG) in Micro-Grid

IEEE Access, 2023
The constant increase of energy demand and the widespread adoption of renewable energy sources have led to the significant interest in micro-grids, which are small-scale power systems that utilize distributed energy resources.
Jianfeng Wang, Nurulazlina Ramli, Noor Hafizah Abdul Aziz   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Self-Organized Synchronization and Voltage Stability in Networks of Synchronous Machines

, 2013
The integration of renewable energy sources in the course of the energy transition is accompanied by grid decentralization and fluctuating power feed-in characteristics. This raises new challenges for power system stability and design.
Friedrich, Rudolf, Kamps, Oliver, Peinke, Joachim, Schmietendorf, Katrin   +3 more
core   +1 more source

Robust Decentralized Secondary Frequency Control in Power Systems: Merits and Trade-Offs [PDF]

, 2018
Frequency restoration in power systems is conventionally performed by broadcasting a centralized signal to local controllers. As a result of the energy transition, technological advances, and the scientific interest in distributed control and ...
De Persis, Claudio, Dörfler, Florian, Jiang, Yan, Mallada, Enrique, Weitenberg, Erik, Zhao, Changhong   +5 more
core   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source