Results 201 to 210 of about 339,891 (283)

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Synchronous Nasopharyngeal Carcinoma and Rectal Adenocarcinoma Treated With Integrated Multimodal Therapy: A Case Report and Literature Review. [PDF]

Cureus
AlGazlan NS, AlFakeeh A, AlDohan M, AlZahrani AM.   +3 more
europepmc   +1 more source

Diffuse Skin Sclerosis in a Patient With Lung Cancer

JEADV Clinical Practice, EarlyView.
Anna‐Sophia Leven, Eva Hadaschik, Alpaslan Tasdogan   +2 more
wiley   +1 more source

A single‐molecule prodrug synergistically suppresses MYC‐amplified osteosarcoma through sequential nitric oxide release and photodynamic therapy

Smart Molecules, EarlyView.
A cascade‐responsive small‐molecule prodrug (DHU‐NO3) sequentially releases methylene blue (triggered by reactive oxygen species) and nitric oxide (controlled by 405 nm light), enabling precise spatiotemporal coordination of photodynamic therapy and NO gas therapy to effectively inhibit MYC‐amplified osteosarcoma growth.
Shuxin Peng, Jiangpeng Wu, Shasha Wang, Ying Gao, Xuran Guo, Mengpan Li, Youjin Wu, Yun Wang, Zhengdong Cai, Yingqi Hua, Peng Wei, Yinghua Gao, Tao Yi   +12 more
wiley   +1 more source

The Global Airways Unit: A Multidisciplinary Strategy for Early Diagnosis and Comorbidity Detection

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic respiratory diseases impose a large global burden of morbidity, mortality, and cost. The concept of a global airway has become increasingly supported by epidemiologic, mechanistic, and clinical evidence. However, clinical care often remains fragmented between ear, nose, and throat (ENT), allergy, and pulmonology.
Diego M. Conti, Eduardo J. Correa, Alfonso Del Cuvillo, José D. Abdullatif, Francisco J. Alvarez‐Gutiérrez, Remedios Cárdenas Contreras, Stefan Cimbollek, Rocío Corrales Millán, Ana Gómez‐Bastero Fernández, Daniel Pérez‐Chada, Francisco Pérez‐Grimaldi, Alberto E. Rabino, Maria A. Romero‐Falcón, Marcela Soria, José Gregorio Soto‐Campos, Rosario B. Spuches, Juan Maza‐Solano   +16 more
wiley   +1 more source

Effective Control of Synchronous Male Breast and Prostate Cancer with Androgen Deprivation Therapy: A Case Report. [PDF]

Surg Case Rep
Furukawa M, Gondo N, Mitsueda R, Arimura A, Fujiki Y, Kawano J, Kanemitsu S, Teraoka M, Ohi Y, Rai Y, Sagara Y, Sagara Y, Ohno S.   +12 more
europepmc   +1 more source

Small Bowel Cancer: Implications of Preoperative Work‐Up on Surgical Strategy

World Journal of Surgery, EarlyView.
Small bowel cancers comprise a heterogeneous group of malignancies, making diagnosis and treatment challenging. This study aimed to evaluate the ability of preoperative diagnostic work‐up to predict clinical and histopathological findings, facilitate subgroup identification, and support tailored, individualized surgical strategies. Preoperative work‐up
Erik Kjæstad, Espen Thiis‐Evensen, Anita Sveen, Arne Olav Bakka, Johannes Kurt Schultz   +4 more
wiley   +1 more source

Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial

World Journal of Surgery, EarlyView.
There is no consensus on surgical techniques in small bowel cancer, particularly regarding the extent of lymph node dissection and strategic choices according to tumor localization and histological type. Clearance of central lymph node metastases can be challenging, especially when small intestinal neuroendocrine tumor (siNET) metastases give rise to ...
Erik Kjæstad, Espen Thiis‐Evensen, Bjørn Edwin, Arne Olav Bakka, Anne Helene Lilleaas, Yngve Thorsen, Johannes Kurt Schultz   +6 more
wiley   +1 more source

Synchronous Metastatic Esophageal Squamous Cell Carcinoma and Acute Myeloid Leukemia: A Case Report. [PDF]

Cancer Manag Res
Abbas Y, Aldakak MA, Hdeoa H, Ibrahim B, Souleiman Y.   +4 more
europepmc   +1 more source

Effects of Lymphatic and Venous Invasion Status on Postoperative Prognosis and Metastasis Pattern in Patients With Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Study

World Journal of Surgery, EarlyView.
Lymphovascular invasion (LVI) is a recognized predictor of poor postoperative outcomes in patients with esophageal squamous cell carcinoma (ESCC). However, only a few studies have evaluated lymphatic invasion (LI) and venous invasion (VI) separately across contemporary perioperative strategies.
Nao Kitasaki, Yoichi Hamai, Yuta Ibuki, Naoto Kishi, Manato Ohsawa, Tomoaki Kurokawa, Morihito Okada   +6 more
wiley   +1 more source