Results 231 to 240 of about 339,891 (283)

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Brain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri, Sung‐Hye Park, Yue‐Shan Piao, Tarik Tihan, Ho‐Keung Ng, Michael Buckland, Rakesh Jalali, Yonehiro Kanemura, Pieter Wesseling, Takashi Komori   +12 more
wiley   +1 more source

Synchronous medullary carcinoma of the pancreas and non-ampullary duodenal adenocarcinoma. [PDF]

Arch Clin Cases
D'Avila L, Tee JY, Sharma A, Alabraba E, Zaitoun AM.   +4 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Atypical Fibroxanthoma on the Scalp of a 74-Year-Old Male with an Incidental Finding of an Amelanotic Melanoma on the Back. [PDF]

Clin Cosmet Investig Dermatol
Chlebicka I, Byrska M, Knecht-Gurwin K, Pradhan A, Stefaniak A, Woźniak Z, Łazicka P, Szepietowski JC.   +7 more
europepmc   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Synchronous Endometrioid Adenocarcinoma of the Ovary and Endometrium in a 37-Year-Old Nulligravid Woman: A Case Report. [PDF]

Cureus
Manivasagham K, Nair A, S I, Kt T.
europepmc   +1 more source

Spatiotemporal CD8+ T‐Cell Dynamics: Clonal Replacement and Expansion as Determinants of Sustainable Antitumor Response

Cancer Science, EarlyView.
Durable antitumor immunity depends on continuous clonal replacement: immune checkpoint inhibitors that drive sustainable, polyclonal mobilization of T‐cell clones from tumor‐draining lymph nodes sustain tumor control, whereas limited, oligoclonal mobilization allows pre‐existing clones to become exhausted, leading to immune escape.
Satoshi Ueha, Hiroyasu Aoki, Munetomo Takahashi, Shigeyuki Shichino, Kouji Matsushima   +4 more
wiley   +1 more source

Case Report: Fatal convergence of two confirmed and one radiologically suspected synchronous urological malignancies in a young patient: ultra-late clear cell renal cell carcinoma recurrence, contralateral renal tumor, and metastatic prostate cancer. [PDF]

Front Oncol
Maachi Y, Fadriq H, El Kacemi H, Kebdani T, Slaoui A, Karmouni T, Koutani A, Elhassouni K, Elkhader K.   +8 more
europepmc   +1 more source

Cell‐Migration Visualization: Task Taxonomy, Systematic Review and Research Agenda

Computer Graphics Forum, EarlyView.
We present an expert‐validated task taxonomy for cell migration analysis and a PRISMA‐based systematic review that maps visualization tools to the tasks they support and the techniques they employ. This synthesis identifies current gaps and outlines opportunities for future research in cell migration visualization.
Ana Carla Correia, Thifany Souza, Ana Carolina Correia, Nivan Ferreira   +3 more
wiley   +1 more source

Dual Immune Checkpoint Blockade in Synchronous Hepatocellular and Renal Cell Carcinoma: A Real-World Case Report of Durable Dual Response. [PDF]

Oncol Res
Federico P, Canciello MA, Granata B, Bosso D, Daniele B.   +4 more
europepmc   +1 more source