Results 151 to 160 of about 129,816 (327)

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

open access: yesAdvanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria   +5 more
wiley   +1 more source

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

open access: yesAdvanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan   +12 more
wiley   +1 more source

Bacterial Foreignization Nanosystem Elicits Multi‐Phenotypic T Cells for Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
In this study, a comprehensive strategy for tumor immunogenicity reshaping is implemented, in which all adjuvanticity, antigenicity, and reactogenicity of tumor cells are highly improved by an engineered bacterial nanosystem through a selective membrane fusion process. The resulting foreignized tumor cells evoke potent innate immune responses, inducing
Wan‐Ru Zhuang   +10 more
wiley   +1 more source

Diagnostic Dilemma of Cardiac Syncope in Pediatric Patients [PDF]

open access: yes, 2008
Aims Syncope is defined as temporary loss of consciousness and postural tone resulting from an abrupt transient decrease in cerebral blood flow. The present work aimed at determining how diagnostic tests are used in the evaluation of pediatric
Aya M Fattouh   +3 more
core  

Self‐Assembled Moiré Superlattices of Ti3C2Tx MXene for Future Twistronic Applications

open access: yesAdvanced Science, EarlyView.
Scanning tunneling microscopy imaging reveals self‐assembled Moiré superlattices in MXene with distinct periodicities. The observed Moiré modulates the local density of states due to interlayer electronic coupling. This work provides an atomic‐scale understanding of MXene Moiré physics and establishes a foundation for twistronics in future quantum ...
Kuanysh Zhussupbekov   +9 more
wiley   +1 more source

Syncope and the risk of sudden cardiac death: Evaluation, management, and prevention

open access: yesJournal of Arrhythmia, 2017
Syncope is a clinical syndrome defined as a relatively brief self-limited transient loss of consciousness (TLOC) caused by a period of inadequate cerebral nutrient flow. Most often the trigger is an abrupt drop of systemic blood pressure.
Ryan J. Koene, MD   +2 more
doaj  

Hierarchical Prediction and Perturbation of Chromatin Organization Reveal How Loop Domains Mediate Higher‐Order Architectures

open access: yesAdvanced Science, EarlyView.
HiCGen introduces a hierarchical deep learning framework to predict genome organization across spatial scales using DNA sequences and genomic features. The model enables cross‐cell‐type predictions and in silico perturbation analysis, revealing correlations between loop domains and higher‐order structures.
Jiachen Wei, Yue Xue, Yi Qin Gao
wiley   +1 more source

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