Results 181 to 190 of about 132,336 (328)
Advanced Science, EarlyView.The TIDE‐Cas14a system, an integrated RPA‐T7‐CRISPR/Cas14a cascade platform incorporating engineered crRNA mismatches, enables ultrasensitive detection of the PIK3CA H1047R mutation in breast cancer circulating tumor DNA, with a limit of detection as low as 0.01%, surpassing the sensitivity of droplet digital PCR.
Yuanyuan Yu +19 more
wiley +1 more source
Advanced Science, EarlyView.Fumadó Navarro et al. present an optimized strategy to generate vascular‐like networks that infiltrate within cerebral organoids with promising signs of blood‐brain barrier characteristics, preserved stiffness, uniform morphology, enhanced media diffusion, and reduced necrotic core.
Josep Fumadó Navarro +7 more
wiley +1 more source
Nanofluid‐Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles
Advanced Science, EarlyView.Incorporating polymeric nanoparticles, PEDOT:PSS, with a high near‐infrared absorption coefficient into the fluid significantly enhances the dusting efficiency of Ho:YAG laser lithotripsy for kidney stone treatment. This approach, which leverages the control of light‐matter interactions, integrates seamlessly with the current laser lithotripsy workflow.
Qingsong Fan +10 more
wiley +1 more source
An “s‐Electron” Donor Band Driven Metallic Ferromagnetism in Co‐Doped ZnO Films
Advanced Science, EarlyView.Hard X‐ray photoemission spectroscopy with polarization dependence enables orbital‐selective probing of buried electronic states. By tuning the incident light's polarization vector, symmetry‐resolved spectral features of core and valence states are revealed, offering deeper insights into orbital hybridization and spin–orbit interactions in functional ...
Pei‐Yu Chuang +9 more
wiley +1 more source
Advanced Science, EarlyView.The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan +5 more
wiley +1 more source
Clinical Practice and Cases in Emergency Medicine, 2017 Dwyer, Kristin H., Rempell, Joshua S.
openaire +6 more sources
Advanced Science, EarlyView.This study resolves conflicting roles of Co⁴⁺ species in cobalt‐based oxygen evolution reaction (OER) catalysts by engineering precursor polymorphism. Through controlled annealing of cobalt oxysulfide, researchers selectively stabilize γ‐CoO2 (enabling oxygen pathway mechanism) and β‐CoO2 (following conventional mechanism). γ‐CoO2 demonstrates superior
Zhongheng Li +9 more
wiley +1 more source
Advanced Science, EarlyView.A multifunctional, zwitterionic nanocellulose‐based coating is developed with lysine modification and polyacrylic acid integration, enabling robust antifogging and antifouling performance. With excellent hydrophilicity, mechanical strength, and biocompatibility, the coating shows promising potential for use in medical, food, and marine applications ...
Yanyi Duan +12 more
wiley +1 more source
Advanced Science, EarlyView.Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou +16 more
wiley +1 more source
A Tick of the Clock: Finding the Sweet Spot in Tilt Table Test. The Effectiveness of Short-Duration Head-Up Tilt Test as a Diagnostic Tool in Suspected Vasovagal Patients: A Retrospective Observational Study in a Tertiary Syncope Unit. [PDF]
J ArrhythmKalhor P +4 more
europepmc +1 more source