Results 181 to 190 of about 123,454 (294)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Impact of physical activity on presentation and prognosis of Brugada syndrome. [PDF]

Open Heart
Fernandez Gil MJ, Carrillo Mora LM, Fernandez Vazquez D, Melgarejo F, Santos Mateo JJ, Muñoz Esparza C, Rodriguez Serrano AI, Navarro-Penalver M, Sanchez Muñoz JJ, Gimeno-Blanes FJ, Sabater-Molina M, Gimeno JR.   +11 more
europepmc   +1 more source

Is vasovagal syncope a disease? [PDF]

, 2007
Paoló Alboni, Michele Brignole, Ettore C. degli Uberti   +2 more
openalex   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Diagnostic and prognostic value of troponins and natriuretic peptides in syncope: a systematic review and meta-analysis. [PDF]

Cardiovasc Diagn Ther
Li S, Liu J, Wang Y, Lai D, Xie Z.
europepmc   +1 more source

Probing Ultrastrong Through‐Space Electronic Coupling in Donor‐Acceptor Systems at the Single‐Molecule Level

Advanced Science, EarlyView.
A series of through‐space coupled donor‐acceptor (D–A) molecules is sandwiched between two electrodes to determine their single‐molecule conductance. As the D–A interaction weakens, single‐molecule conductance reduces while Flicker Noise PSD n‐value increases (coupling strength decreases).
Xin Wang, Dan Yang, Jiazheng Diao, Jens Ulstrup, Chengyang Zhang, Florian Auras, Qiang Fu, Jinlong Yang, Linsong Cui, Yueqi Li, Jinghong Li   +10 more
wiley   +1 more source

Nocturnal Heart Rate Variability in Unexplained Syncope and Sleep Apnea-The SINCOSAS Study. [PDF]

J Clin Med
Muñoz-Martínez MJ, Casal-Guisande M, Sopeña B, Torres-Durán M, García-Campo E, Corbacho-Abelaira D, Souto-Alonso A, Fernández-Villar A.   +7 more
europepmc   +1 more source

The prevalence and clinical features of syncope in patients with concealed Brugada Syndrome [PDF]

B Hunuk, O Cagac, Oğuzhan Ekrem Turan, F Besiroglu, Ömer Kozan   +4 more
openalex   +1 more source

Correction to: 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.

Circulation, 2017
L. Wilkins
semanticscholar   +1 more source

Enhancing Chemical Stability and Molecular Selectivity of Porous Organic Cages via Core–Shell Polymer Coating

Advanced Science, EarlyView.
This study presents an interfacial method to fabricate POC@polymer core–shell nanostructures combining cage porosity with polymer robustness. Through chiral self‐assembly and non‐solvent‐induced surface polymerisation, uniform ∼20 nm polymer‐coated particles are produced.
Danyu Li, Yanling Huang, Huiyu Liu, Yuzhen Wen, Dongxu Wang, Tao Li, Shan Jiang   +6 more
wiley   +1 more source