Results 241 to 250 of about 11,102 (261)
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The FASEB Journal, 2003
ABSTRACT Cell surface heparan sulfate (HS) influences a multitude of molecules, cell types, and processes relevant to inflammation. HS binds to cell surface and matrix proteins, cytokines, and chemokines. These interactions modulate inflammatory cell maturation and activation, leukocyte rolling, and tight adhesion to endothelium, as ...
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ABSTRACT Cell surface heparan sulfate (HS) influences a multitude of molecules, cell types, and processes relevant to inflammation. HS binds to cell surface and matrix proteins, cytokines, and chemokines. These interactions modulate inflammatory cell maturation and activation, leukocyte rolling, and tight adhesion to endothelium, as ...
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Syndecan-4-mediated signalling
Cellular Signalling, 2001The paradigm of cell surface proteoglycan function has been centered on the role of the ectoplasmic heparan sulfate (HS) chains as acceptors of a wide array of ligands, including extracellular matrix (ECM) proteins and soluble growth factors. Within this picture, the core proteins were assigned only a passive role of carrying the glycosaminoglycan (GAG)
M, Simons, A, Horowitz
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Cell and Tissue Research, 2016
Heart disease is a deadly syndrome affecting millions worldwide. It reflects an unmet clinical need, and the disease mechanisms are poorly understood. Cardiac fibrosis is central to heart disease. The four-membered family of transmembrane proteoglycans, syndecan-1 to -4, is believed to regulate fibrosis.
Ida G, Lunde +3 more
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Heart disease is a deadly syndrome affecting millions worldwide. It reflects an unmet clinical need, and the disease mechanisms are poorly understood. Cardiac fibrosis is central to heart disease. The four-membered family of transmembrane proteoglycans, syndecan-1 to -4, is believed to regulate fibrosis.
Ida G, Lunde +3 more
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Syndecan-4: Dispensable or indispensable?
Glycoconjugate Journal, 2002Studies examining the role of the cell-surface heparan sulfate proteoglycan syndecan-4 have yielded a plethora of information regarding its role in both cell-matrix and growth-factor mediated signaling events. Many of the initial conclusions drawn from such research placed syndecan-4 in a keystone position within various signaling pathways though the ...
Wilcox Adelman SA +5 more
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2001
Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors ...
Couchman, J R, Chen, L, Woods, A
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Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors ...
Couchman, J R, Chen, L, Woods, A
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Syndecan proteoglycans and cell adhesion
Matrix Biology, 1998It is now becoming clear that a family of transmembrane proteoglycans, the syndecans, have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization.
Woods, A, Oh, E S, Couchman, J R
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Science's STKE, 2005
Syndecans, transmembrane heparan sulfate (HS) proteoglycans that regulate the activity of various growth factors and adhesion molecules, interact through their cytoplasmic domains with the PDZ domain-containing protein syntenin. Zimmermann et al.
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Syndecans, transmembrane heparan sulfate (HS) proteoglycans that regulate the activity of various growth factors and adhesion molecules, interact through their cytoplasmic domains with the PDZ domain-containing protein syntenin. Zimmermann et al.
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