Results 71 to 80 of about 4,352,139 (301)

Myelodysplastic syndromes and overlap syndromes

BLOOD RESEARCH, 2021
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological neoplasms characterized by ineffective hematopoiesis, morphologic dysplasia, and cytopenia. MDS overlap syndromes include various disorders, such as myelodysplastic/myeloproliferative neoplasms and hypoplastic MDS with aplastic anemia characteristics.
openaire   +3 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Serotonin Syndrome

Annals of Indian Academy of Neurology, 2021
Sanjay Prakash, Chaturbhuj Rathore, Kaushik Rana   +2 more
openaire   +4 more sources

Fetal alcohol syndrome; guidelines for referral and diagnosis [PDF]

National Center on Birth Defects and Developmental Disabilities in coordination with National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effect (American Academy of Pediatrics, American College of Obstetricians and Gynecologists, March of ...

core  

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Consistent unmet needs and fragmented care in Rett syndrome: insights from a multi-country European caregiver study

Orphanet Journal of Rare Diseases
Background Rett syndrome is a rare neurodevelopmental disorder associated with functional impairments that emerge in early childhood and persist throughout life. Despite improved understanding of its genetic basis and natural history, therapeutic options
Tom Pulles, Becky Jenner, Mariëlle van den Berg, Pedro Rocha, Angela De Martini, Kees Chamberlain, Harish Grandjean   +6 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Congenital Bilateral Aniridia with Ectopia Lentis: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Aniridia is characterised by variable degrees of hypoplastic iris or complete absence of iris tissue and is a rare congenital disorder. Mutation in the PAX6 gene is mostly responsible for aniridia.
Vijaya Mallareddy, Sachin Daigavane, Pranaykumar Shinde   +2 more
doaj   +1 more source

Is Socioeconomic Position Related to the Prevalence of Metabolic Syndrome? Influence of social class across the life course in a population-based study of older men [PDF]

, 2008
OBJECTIVE - To examine whether adult social class and childhood social class are related to metabolic syndrome in later life, independent of adult behavioral factors.RESEARCH DESIGN AND METHODS - This was a population-based cross-sectional study ...
Morris, R, Lennon, Lucy, Whincup, Peter H, Whincup, PH, Morris, Richard, Ramsay, SE, Lennon, L, Ramsay, Sheena E, Wannamethee, S G, Wannamethee, SG   +9 more
core   +1 more source