Results 281 to 290 of about 957,593 (356)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Synergistic Effect of Poly(ethylenephosphoric Acid) and Cerium in Bone Substitute Composites on Tissue Response and Bone Remodeling. [PDF]

Int J Mol Sci
Besprozvannykh V, Ryndyk M, Nifant'ev I, Tavtorkin A, Gavrilov D, Lukina Y, Bionyshev-Abramov L, Serejnikova N, Smolentsev D, Ivchenko P.   +9 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Synergistic effect study on the co-delivery of paclitaxel and SiRNA targeting STMN1 based on MPDA nanoparticles in the therapy of ovarian cancer. [PDF]

J Nanobiotechnology
Qian X, Yuan Y, Zhang Y, Li M, Wang X, Li W, Wen L, Duan G, Han Y.   +8 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Synergistic Effect of Acupuncture and Traditional Chinese Medicine on Cerebral Infarction in Rats: Roles of Short-Chain Fatty Acids and Interleukin-17. [PDF]

Int J Gen Med
Kang Z, Lin P, Chen Z, Ye H, Fang L, Zhang P.   +5 more
europepmc   +1 more source

Synergistic Effect of Cobalt/Ferrocene as a Catalyst for the Oxygen Evolution Reaction

José M. Abad, Alba Duprat-Alvaro, Raquel Sainz, M.V. Martı́nez-Huerta, Marcos Pita, António L. De Lacey   +5 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Synergistic Effect of Liraglutide and Strength-Endurance Exercise Training on Hepatic Oxidative Stress and Lipid Metabolism in Middle-Aged Male Rats. [PDF]

Antioxidants (Basel)
Vlahović D, Trifunović S, Borković-Mitić S, Pavlović S, Gizdović I, Lütjohann D, Filipović B, Marina L, Šošić-Jurjević B.   +8 more
europepmc   +1 more source