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Quantitative Methods for Assessing Drug Synergism [PDF]
Genes and Cancer, 2011 Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.
Ronald Tallarida
exaly +6 more sources
Current Research in Pharmacology and Drug Discovery, 2022 Current cancer therapy includes a variety of strategies that can comprise only one type of treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for cancer therapy, though sometimes associated with undesired side ...
Diana Duarte, Nuno Vale
doaj +4 more sources
CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts. [PDF]
Sci Rep, 2022 Anticancer combination therapy has been developed to increase efficacy by enhancing synergy. Patient-derived xenografts (PDXs) have emerged as reliable preclinical models to develop effective treatments in translational cancer research. However, most PDX
Huang L +5 more
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Mycobacterium Time-Series Genome Analysis Identifies AAC2' as a Potential Drug Target with Naloxone Showing Potential Bait Drug Synergism. [PDF]
Molecules, 2022 The World Health Organization has put drug resistance in tuberculosis on its list of significant threats, with a critical emphasis on resolving the genetic differences in Mycobacterium tuberculosis. This provides an opportunity for a better understanding
Niranjan V +5 more
europepmc +2 more sources
Drug Synergism as the Basis of Rational Neuroprotection. [PDF]
Neurosci Behav Physiol, 2022 Optimization of the choice of neuroprotective therapy regimens in patients with cerebrovascular diseases (CVD), taking into account the synergism of drug interactions, is a basic approach in clinical practice. Unfortunately, modern pharmacology has no unified way of establishing synergistic spectra of drug actions, which would allow systematic ...
Putilina MV, Teplova NV.
europepmc +3 more sources
Drug Discovery TodayIn the context of the multitarget paradigm, fixed-dose combination (FDC) drugs, that is, compounds that synergistically target multiple sites when combined, have gained attention for treating complex diseases like cancers and viral infections, as ...
Jack Tuszyński +2 more
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Predicting Synergism of Cancer Drug Combinations Using NCI-ALMANAC Data
Frontiers in Chemistry, 2019 Drug combinations are of great interest for cancer treatment. Unfortunately, the discovery of synergistic combinations by purely experimental means is only feasible on small sets of drugs. In silico modeling methods can substantially widen this search by
Pavel Sidorov +5 more
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An R Package for Assessing Drug Synergism/Antagonism
Journal of Statistical Software, 2010 Synergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs. Boik, Newman, and Boik (2008) proposed the MixLow method as an alternative to the Median-Effect method of Chou and ...
John C. Boik, Balasubramanian Narasimhan
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Antimalarial drug synergism and antagonism: Mechanistic and clinical significance [PDF]
FEMS Microbiology Letters, 2005 Interactions between antimicrobial agents provide clues as to their mechanisms of action and influence the combinations chosen for therapy of infectious diseases. In the treatment of malaria, combinations of drugs, in many cases acting synergistically, are increasingly important in view of the frequency of resistance to single agents.
A. Bell
openaire +3 more sources
Revisiting the isobole and related quantitative methods for assessing drug synergism. [PDF]
J Pharmacol Exp Ther, 2012 Tallarida RJ.
europepmc +2 more sources