Results 21 to 30 of about 1,947,705 (257)
BMC Cancer, 2021 Background One key approach for anticancer therapy is drug combination. Drug combinations can help reduce doses and thereby decrease side effects. Furthermore, the likelihood of drug resistance is reduced.
Jonas Parczyk +9 more
doaj +1 more source
Evaluation the combination of chlorpheniramine and tramadol at a level of thermal and visceral antinociceptive in a mouse acute pain model [PDF]
Iraqi Journal of Veterinary Sciences, 2023 The possible benefits of employing combination treatment include the ability to increase antinociceptive effects while minimizing the occurrence of unfavorable side effects.
Ali I. Thannon, Gada A. Faris
doaj +1 more source
Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease
Brain Sciences, 2021 Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs).
Hafsa Amat-ur-Rasool +3 more
doaj +1 more source
Frontiers in Oncology, 2021 The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this regard, drug repurposing or repositioning can represent a safe, swift, and inexpensive way to bring ...
Silvia Matteoni +9 more
doaj +1 more source
Неврология, нейропсихиатрия, психосоматика, 2021 Objective: to establish the molecular mechanisms of interaction of cytidine-diphosphocholine choline (CDP-choline) with other agents used to treat chronic cerebral ischemia (CCI) to increase the effectiveness of the therapy..Material and methods.
I. Yu. Torshin +6 more
doaj +1 more source
Interpreting the Mechanism of Synergism for Drug Combinations Using Attention-Based Hierarchical Graph Pooling [PDF]
, 2023 Synergistic drug combinations provide huge potentials to enhance therapeutic efficacy and to reduce adverse reactions. However, effective and synergistic drug combination prediction remains an open question because of the unknown causal disease signaling
Heming Zhang +10 more
core +1 more source
Antinociceptive synergism in preclinical studies: A review [PDF]
, 2022 In the treatment of acute and chronic pain the most frequently used drugs are nonsteroidal anti-inflammatory drugs (NSAIDs), e.g., paracetamol; opioids, e.g., tramadol, and a group of drugs called coanalgesics or adjuvants (e.g., antidepressants ...
Noriega, Viviana +4 more
core +1 more source
Biomedicines, 2023 Despite the options available for breast cancer (BC) therapy, several adverse effects and resistance limit the success of the treatment. Furthermore, the use of a single drug is associated with a high failure rate.
Lyvia Eloiza de Freitas Meirelles +9 more
doaj +1 more source
Biomolecules, 2022 Despite the progressive research and recent advances in drug therapy to treat solid tumours, the number of cases and deaths in patients with cancer is still a major health problem.
Diana Duarte +3 more
doaj +1 more source
Development of Repetitive Synergism in Calitropis procera Extract with Ampicillin for Combating Drug Resistance in Clinical Bacteria and Identification of its Bioactive Components using GS-MS Analysis. [PDF]
, 2023 The pursuit of innovative approaches to develop lead compounds that exhibit selectivity, efficacy, and safety as potential candidates for clinical trials poses a significant scientific challenge.
Mathew, Gideon +2 more
core +1 more source