Results 11 to 20 of about 1,832,998 (303)
Quantitative Methods for Assessing Drug Synergism [PDF]
Genes and Cancer, 2011 Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.
Ronald Tallarida
exaly +5 more sources
Drug Synergism as the Basis of Rational Neuroprotection. [PDF]
Neurosci Behav Physiol, 2022 Optimization of the choice of neuroprotective therapy regimens in patients with cerebrovascular diseases (CVD), taking into account the synergism of drug interactions, is a basic approach in clinical practice. Unfortunately, modern pharmacology has no unified way of establishing synergistic spectra of drug actions, which would allow systematic ...
Putilina MV, Teplova NV.
europepmc +3 more sources
Frontiers in Oncology, 2021 The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this regard, drug repurposing or repositioning can represent a safe, swift, and inexpensive way to bring ...
Silvia Matteoni +9 more
doaj +3 more sources
Mycobacterium Time-Series Genome Analysis Identifies AAC2′ as a Potential Drug Target with Naloxone Showing Potential Bait Drug Synergism [PDF]
Molecules, 2022 Vidyā Niranjan, Akshay Uttarkar
exaly +2 more sources
Biomolecules, 2020 Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy ...
Diana Duarte, Nuno Vale
doaj +3 more sources
Synergistic anti-cancer effects of silibinin-etoposide combination against human breast carcinoma MCF-7 and MDA-MB-231 cell lines [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Recently, there is a significant focus on combination chemotherapy for cancer using a cytotoxic drug and a phytochemical compound. We investigated the effect of silibinin on etoposide-induced apoptosis in MCF-7 and MDA-MB-231 breast ...
Mahdie Koushki +4 more
doaj +1 more source
Development of an optimised application protocol for sonophoretic transdermal delivery of a model hydrophilic drug [PDF]
, 2011 It has now been known for over a decade that low frequency ultrasound can be used to effectively enhance transdermal drug penetration - an approach termed sonophoresis.
Abdul, Rasool +3 more
core +4 more sources
Gels, 2022 Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on
Naved Azum +4 more
doaj +1 more source
In vitro and in vivo antimicrobial activity of an active plant-based quadrocomplex for skin hygiene [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: The current epidemiological situation causes a new surge of interest to perspective antimicrobial formulations for proper skin hygiene. Aims: To evaluate in vitro and in vivo the antimicrobial activity of a novel active quadrocomplex (QC) for
Viktor A. Filatov +2 more
doaj +1 more source
BMC Cancer, 2021 Background One key approach for anticancer therapy is drug combination. Drug combinations can help reduce doses and thereby decrease side effects. Furthermore, the likelihood of drug resistance is reduced.
Jonas Parczyk +9 more
doaj +1 more source