Results 41 to 50 of about 1,947,705 (257)

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Associated with Mycoplasma pneumoniae Infection

open access: yesCase Reports in Dermatology, 2020
Mycoplasma infection may lower the threshold for drug allergy in particular patients. We present a case of drug reaction with eosinophilia and systemic symptoms (DRESS), with drug etiology and non-drug etiology (Mycoplasma infection).
Guy Shalom, Raed Khoury, Amir Horev
doaj   +1 more source

A schematic of NB synergism (A) and additive synergism (B).

open access: yes, 2014
Response for AE curve = effect of drug 1 alone+effect of drug 2 alone. The maximal difference between peak value and endpoints of NB curves determines the maximum NB synergism.
John H. Byrne (145197)   +3 more
core   +1 more source

Mechanisms Underlying the Action and Synergism of Trastuzumab and Pertuzumab in Targeting HER2-Positive Breast Cancer

open access: yes, 2018
Human epidermal growth factor receptor (HER) 2 (HER2) is overexpressed in 20–30% of breast cancers. HER2 is a preferred target for treating HER2-positive breast cancer. Trastuzumab and pertuzumab are two HER2-targeted monoclonal antibodies approved
Zhixiang Wang, Hamid Maadi, Babak Nami
core   +1 more source

Tests of synergism between nicotine and the pyrethrins

open access: yes, 1953
Synergism between nicotine and pyrethrum applied by injection to adult Oncopeltus fasciatus Dal. has been reported by Turner (1951). When these insecticides were applied alone and as a mixture to adult Tribolium castaneum Hbst., using a dipping ...
Bliss, C. I., Turner, N.
core   +1 more source

The cardiovascular effects of midazolam co-induction to propofol for induction in aged patients [PDF]

open access: yesKorean Journal of Anesthesiology, 2012
BackgroundThe aim of this study was to investigate whether a small dose of midazolam and lessening the propofol dosage could prevent cardiovascular change at tracheal intubation for induction in aged patients.MethodsEighty patients over 65 years (ASA ...
Young Soo Lim   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Drug–drug interactions

open access: yes, 2018
A drug interaction occurs when the effects of a drug are altered by the effects of another drug, a vaccine, herb, foodstuff, or device. In drug–drug interactions, a precipitant drug increases or reduces the effects of an object drug by pharmaceutical ...
Jeffrey K. Aronson
core   +1 more source

Effect of 5-Fluorouracil Administered at Low Doses on Cytotoxic Properties of Methotrexate in the in vivo Model of Mice L1210 Leukemia; According to the Schedule of Treatment

open access: yesPteridines, 1994
The study compared antineoplastic effects of combined methotrexate and 5-fluorouracil therapy on LI210 lymphoid leukemia in mice according to the schedule of treatment. Methotrexate was administered at doses of: LOw.. 0.5 LOw.
Graczyk Julita
doaj   +1 more source

Supramolecular assemblies of rifampicin and cationic bilayers: preparation, characterization and micobactericidal activity

open access: yesBMC Biotechnology, 2011
Background Cationic bilayers based on the inexpensive synthetic lipid dioctadecyldimethylammonium bromide (DODAB) have been useful as carriers for drug delivery, immunoadjuvants for vaccines and active antimicrobial agents.
Mamizuka Elsa M   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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