Results 51 to 60 of about 82,422 (345)

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

Development of gradient diffusion strips to identify the potentiating effect of antimicrobial compounds against multidrug-resistant Klebsiella pneumoniae strains [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. The aim of the study was to develop gradient diffusion strips with substances capable of potentiating the action of antibiotics for the treatment of infections caused by multidrug-resistant strains of K. pneumoniae.
Likhachev I.V., Kaftyreva L.A., Samoilova A.A., Kraeva L.A., Mikhailov N.V.   +4 more
doaj   +1 more source

Increasing the Efficacy of Treatment of Staphylococcus aureus–Candida albicans Mixed Infections with Myrtenol

Antibiotics, 2022
Infectious diseases caused by various nosocomial microorganisms affect worldwide both immunocompromised and relatively healthy persons. Bacteria and fungi have different tools to evade antimicrobials, such as hydrolysis damaging the drug, efflux systems,
Ruba Y. Mahmoud, Elena Y. Trizna, Rand K. Sulaiman, Roman S. Pavelyev, Ilmir R. Gilfanov, Svetlana A. Lisovskaya, Olga V. Ostolopovskaya, Larisa L. Frolova, Alexander V. Kutchin, Galina B. Guseva, Elena V. Antina, Mikhail B. Berezin, Liliya E. Nikitina, Airat R. Kayumov   +13 more
doaj   +1 more source

High potency of melaleuca alternifolia essential oil against multi-drug resistant gram-negative bacteria and methicillin-resistant staphylococcus aureus [PDF]

, 2018
Purpose: Herein, an extended investigation of Tea tree oil (TTO) against a number of multi-drug resistant (MDR) microorganisms in liquid and vapor phases is reported.
Božović, Mijat, Costantini, Silvia, De Angelis, Massimiliano, Garzoli, Stefania, Mascellino, Maria Teresa, Oliva, Alessandra, Ragno, Rino, Vullo, Vincenzo   +7 more
core   +1 more source

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Associated with Mycoplasma pneumoniae Infection

Case Reports in Dermatology, 2020
Mycoplasma infection may lower the threshold for drug allergy in particular patients. We present a case of drug reaction with eosinophilia and systemic symptoms (DRESS), with drug etiology and non-drug etiology (Mycoplasma infection).
Guy Shalom, Raed Khoury, Amir Horev
doaj   +1 more source

Radiosensitization of noradrenaline transporter-expressing tumour cells by proteasome inhibitors and the role of reactive oxygen species [PDF]

, 2013
Background The radiopharmaceutical 131I-metaiodobenzylguanidine (131I-MIBG) is used for the targeted radiotherapy of noradrenaline transporter (NAT)-expressing neuroblastoma.
Babich, J.W., Boyd, M., Mairs, R.J., Rae, C., Tesson, M.   +4 more
core   +3 more sources

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter [PDF]

, 2012
Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA ...
Babich, John W, Boyd, Marie, Champion, Sue, Gaze, Mark N, Mairs, Robert J, McCluskey, Anthony G, Pimlott, Sally L, Tesson, Mathias   +7 more
core   +1 more source

The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class-Effect Synergy in Experimental Arthritis [PDF]

, 2013
PMCID: PMC3564948This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Grieder, Adam Al-Kashi, AE Koch, AJ Janckila, B Joe, BC Sondergaard, C Di Filippo, C Gannon, DD Brand, DH Copp, DR Mitchell, E Smith, F Buttgereit, GR Zimmermann, H Schacke, H Smolian, I MacIntyre, JA Cidlowski, JA Da Silva, JA Whitworth, James P. Gilligan, JB Smith, JJ Body, JM Stuart, John Wallace, K De Bosscher, K Henriksen, KS Kim, L Mancini, LI Plotkin, M Cochran, M Paul-Clark, M Yamaguchi, M Yamaguchi, M Yamaguchi, M Zaidi, MA Karsdal, MA Karsdal, Mauro Perretti, MF Fredin, MJ Peters, MR Edwards, N Binkley, N Mukaida, Niloufar Moradi-Bidhendi, Nozer Mehta, PJ Barnes, PJ Barnes, RA Nathan, RI Scheinman, S Aida, S van Wetering, SE Abdullahi, T Rhen, Trinidad Montero-Melendez, YH Chang   +55 more
core   +5 more sources

The cardiovascular effects of midazolam co-induction to propofol for induction in aged patients [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundThe aim of this study was to investigate whether a small dose of midazolam and lessening the propofol dosage could prevent cardiovascular change at tracheal intubation for induction in aged patients.MethodsEighty patients over 65 years (ASA ...
Young Soo Lim, Dong Hee Kang, Se Hwan Kim, Tae Ho Jang, Kyung Han Kim, Sie Jeong Ryu, Soo Bong Yu, Doo Sik Kim   +7 more
doaj   +1 more source

The role of the Bmi1-GSK3β pathway in glioblastoma [PDF]

, 2010
Malignant gliomas remain one of the deadliest of all cancers despite maximal therapy. They present unique challenges to therapy with a median survival of 12 months.
Korur, Serdar
core   +1 more source