Results 81 to 90 of about 511,945 (268)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Synergistic effects of adjuvant A-134 on the herbicidal effects of glyphosate

Journal of Pesticide Science, 2019
Undesirable side effects on ecosystems and strong selection for weed resistance demand an increase in the efficacy and a reduction in the dosage of glyphosate herbicide used. The synergistic effect of tank-mixed adjuvant KAO® A-134 (A-134) on the post-emergence activity of the commercial glyphosate formulation Roundup® (RDP) against crabgrass ...
Hao, Youwu, Zhang, Yang, Xu, Wenping, Gao, Jufang, Tao, Liming   +4 more
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy

Experimental Hematology & Oncology
Background Tetrahydromagnolol (THM) is a compound isolated from Magnolia officinalis with unique chemical structure and composition. However, its anticancer effect of THM and the underlying molecular mechanisms remain unclear.
Xiaoqing Gu, Lin Li, Ting Duan, Lijun Jin, Qinsong Sheng, Quan Gao, Mengting Chen, Xinbing Sui   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Antibacterial Effect of Amentoflavone and Its Synergistic Effect with Antibiotics

Journal of Microbiology and Biotechnology, 2013
Selaginella tamariscina is a traditional herb used in medicine. Phytochemical amentoflavone, a biflavonoid class of flavonoids, was isolated from the plant of Selaginella tamariscina. In this study, the antibacterial effects and combination effects of amentoflavone and conventional antibiotics such as ampicillin, cefotaxime, and chloramphenicol were ...
Ji Hong, Hwang, Hyemin, Choi, Eun-Rhan, Woo, Dong Gun, Lee   +3 more
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A synergistic effect of herb and acupuncture on the methamphetamine

Integrative Medicine Research
Herbal medicine Ja-Geum-Jeong (JGJ) has been used for the treatment of detoxification in Eastern Asia. However, the mechanisms involved are not clearly defined. The purpose of the present study was to investigate if herb medication inhibits Methamphetamine (METH)'s reinforcing effect and also examined if a combination of herb medication and acupuncture
Jin Gyeom Lee, Yuchi Li, Nam Jun Kim, Han Byeol Jang, Chae Ha Yang, Hee Young Kim, Seong Shoon Yoon, Suchan Chang, Seon-Ju Jeong, Sang Chan Kim, Bok Suk Sa, Bong Hyo Lee   +11 more
openaire   +3 more sources

The synergistic effect of biosynthesized gold nanoparticles with antibiotic against clinical isolates

مجلة مركز بحوث التقنيات الاحيائية, 2019
Background: Antibiotic resistance is a life threating problem and the need for an alternative is increasing worldwide. Objective of this study is: Detecting the combination effect of AuNps with Amoxicillin/clavulanate (AMC) antibiotic against ...
Marwa H. al-khafaji, Mohammed H. Hashim
doaj   +1 more source