Results 131 to 140 of about 604,960 (300)

Polyadic Entropy, Synergy and Redundancy among Statistically Independent Processes in Nonlinear Statistical Physics with Microphysical Codependence

, 2017
The information shared among observables representing processes of interest is traditionally evaluated in terms of macroscale measures characterizing aggregate properties of the underlying processes and their interactions.
Perdigão, Rui A. P.
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Synergistic effects of environmental credit evaluation and emissions trading in promoting enterprise carbon reduction

Frontiers in Environmental Science
This study empirically analyzes the synergistic effects of China’s environmental credit evaluation system and carbon emissions trading policy on enterprise carbon emission intensity.
Jingyuan Wang, Qingfeng Luo
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Impact of the dual pilot policy of Smart Cities and Broadband China strategy on air pollution reduction in China

Discover Sustainability
The strategies of Smart Cities and Broadband China are pivotal policy arrangement for propelling the development of China's digital economy. Accurately assessing their synergistic impact on urban air pollution provides vital insights for flexibly ...
Jingrui Zhao, Genlong Guo
doaj   +1 more source

An Analysis of the Synergistic Effects of Air Pollutant Reduction and Carbon Mitigation in Major Emission Reduction Policies in China’s Transportation Sector

Energies
As of 2023, China’s transportation energy carbon emissions account for over 10%, which has a significant impact on achieving “dual carbon” goals. China has successively issued various policies to address pollution emissions in the transportation industry.
Jingan Zhu, Ping Jiang, Yuanxiang Chen
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Unlocking Urban Breathability: Investigating the Synergistic Mitigation of PM_2.5 and CO₂ by Community Park Green Space in the Built Environment Using Simulation

Buildings
Reducing carbon emissions and controlling air pollution is a dual challenge for China in addressing climate change. Analyzing the synergistic relationship between PM2.5 and CO2 in urban green spaces has become an important part of promoting pollution ...
Xina Ma, Mengyao Wang, Xiaoling She, Jingyuan Zhao   +3 more
doaj   +1 more source