Results 111 to 120 of about 604,960 (300)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Underground SpaceThe prediction of rock cutting force is critical for tunnel boring machine performance and cutterhead design. This paper presents a novel model for rock cutting force prediction based on the Colorado School of Mines (CSM) model, which incorporates the ...
Yadong Xue +4 more
doaj +1 more source
Implications of control technology on aircraft design [PDF]
, 1984 New controls technologies are now available for implementation with aircraft systems. Many aircraft with state of the art technology in the fields of aerodynamics, structures, and propulsion require extensive augmentation merely for safety of flight ...
Arbuckle, P. D., Sliwak, S. M.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Journal of Materials Research and TechnologyThe hydraulic machinery in marine environment is vulnerable to the synergistic damage by high-speed rotating flow, chloride-induced corrosion, and sand particle erosion, which has become the major threat to its safe and efficient operation. In this study,
Kai Wang +5 more
doaj +1 more source
Research on the development and management of clinical pathways Ⅲ: thoughts on the work of clinical pathways under the DRG/DIP payment model of medical insurance payment [PDF]
Yixue xinzhi zazhiChina is actively promoting Diagnosis-Related Group (DRG)/Diagnosis-Intervention Packet (DIP) payment reform alongside the implementation of clinical pathways.
PENG Shuzhen +8 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
ToxicsChina has identified the synergistic reduction of pollution and carbon emissions as a crit ical component of its environmental protection and climate mitigation efforts.
Zimu Jia +4 more
doaj +1 more source
The Potential of Synergistic Static, Dynamic and Speculative Loop Nest Optimizations for Automatic Parallelization [PDF]
, 2010 Research in automatic parallelization of loop-centric programs started with static analysis, then broadened its arsenal to include dynamic inspection-execution and speculative execution, the best results involving hybrid static-dynamic schemes.
Baghdadi, Riyadh +4 more
core +4 more sources