Results 91 to 100 of about 604,960 (300)
Antimicrobial resistance: a biopsychosocial problem requiring innovative interdisciplinary and imaginative interventions [PDF]
, 2018 To date, antimicrobials have been understood through largely biomedical perspectives. There has been a tendency to focus upon the effectiveness of pharmaceuticals within individual bodies.
Bandura A +8 more
core +3 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Energy Strategy ReviewsDigital economy plays a crucial role in promoting synergistic management of agricultural pollution control and carbon reduction. Using panel data from 30 provinces in China from 2011 to 2022, this study measures the synergistic effect of pollution ...
Mengyang Hou +5 more
doaj +1 more source
Fundamental studies of the solid-particle erosion of silicon [PDF]
, 1982 The predictions of the theories of solid-particle erosion of brittle materials are compared to experimental results of studies in which angular Al2O3 particles with mean diameters D of 23 to 270 microns are used to erode (111) surfaces of silicon single ...
Routbort, J. L., Scattergood, R. O.
core +1 more source
Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism [PDF]
, 2017 The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems.
Barrasa, M. Inmaculada +9 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]
, 2012 Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin +2 more
core +5 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Scientific ReportsRealizing the synergistic effect of urban carbon-reduction and water-saving (CRWS) is of great significance for improving the urban carbon-water nexus and promoting urban sustainable development.
Qian Wang, Shouqiang Xu, Zuqin Ding
doaj +1 more source