Results 121 to 130 of about 771,131 (233)

Insufficient evidence for non-neutrality of synonymous mutations. [PDF]

Nature, 2023
Kruglyak L, Beyer A, Bloom JS, Grossbach J, Lieberman TD, Mancuso CP, Rich MS, Sherlock G, Kaplan CD.   +8 more
europepmc   +1 more source

Genomic insights into the local adaptation of spontaneous olive trees in the Mediterranean Basin highlight the need for conservation planning in the face of global change

PLANTS, PEOPLE, PLANET, EarlyView.
The Mediterranean Basin, a major biodiversity hotspot, is highly vulnerable to climate and global changes. Wild olive trees form an essential part of this landscape and hold strong ecological, cultural and socio‐economic significance. By examining how these trees responded to past climatic conditions, this study shows adaptation of olive trees to local
Lison Zunino, Gautier Sarah, Lorenzo Rocchetti, Bénédicte Rhoné, Alexandre Soriano, Gaëtan Droc, Pierre Mournet, Ahmed El Bakkali, Evelyne Costes, Bouchaib Khadari, Philippe Cubry   +10 more
wiley   +1 more source

Effect of CTSS non-synonymous mutations on litter size in Qianbei Ma goats. [PDF]

Front Vet Sci, 2023
Zhang Y, Chen X, Ruan Y, Guo W, Chen J, Tang W, Ji Q, Fu K.   +7 more
europepmc   +1 more source

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source

Synonymous codon-optimized multiplex qPCR for simultaneous detection of Helicobacter pylori and precise drug resistance profiling in infected individuals

Journal of Clinical Microbiology
Antibiotic-resistant Helicobacter pylori (H. pylori) represents a significant global challenge to the efficacy of eradication therapies, underscoring the urgent need for rapid and precise pretreatment resistance profiling.
Hui-Lan Li, Ya-Li Fan, Tian Zhong, Bi-Yu Lin, Qin-Jin Wang, Jia Xie, Ze-Lin Zhang, Shu-Ping Nie, Hong-Lei Chen, Chao Wu   +9 more
doaj   +1 more source

Determining frequencies of fungicide resistance in Leptosphaeria maculans that render demethylation inhibitor fungicides ineffective in the field

Pest Management Science, EarlyView.
As little as 1–10% of the population is needed to be resistant for demethylation inhibitor fungicides to be rendered ineffective. Following a single round of selection, the frequency increases by more than 15% with limited fitness penalty detected when no selection is present.
Alec J McCallum, Alexander Idnurm, Stephen J Marcroft, Andrew H Ware, Elizabeth M Sheedy, Angela P Van de Wouw   +5 more
wiley   +1 more source

The first report of M918L (super‐kdr) and L932F voltage‐gated sodium channel mutations in the English grain aphid (Sitobion avenae)

Pest Management Science, EarlyView.
The study has identified mutations in the voltage gated sodium channel of the English grain aphid (Sitobion avenae) at M918 and L932, which have not been previously reported in this species. Abstract BACKGROUND The grain aphid, Sitobion avenae Fabricius (Hemiptera: Aphididae), is a vector of yellow dwarf viruses and an important pest of cereals.
Virgile Ballandras, Louise McNamara, James C Carolan, Tom Ruttink, Stephen Byrne   +4 more
wiley   +1 more source

Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria. [PDF]

mBio, 2023
Hegelmeyer NK, Parkin LA, Previti ML, Andrade J, Utama R, Sejour RJ, Gardin J, Muller S, Ketchum S, Yurovsky A, Futcher B, Goodwin S, Ueberheide B, Seeliger JC.   +13 more
europepmc   +1 more source

Autosomal recessive dilated cardiomyopathy due to DOLK mutations results from abnormal dystroglycan O-mannosylation [PDF]

, 2011
Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they are thought to contribute considerably to sudden cardiac death and heart failure, especially in young children.
Steenbergen, Gerry, van Reeuwijk, Jeroen, Lefeber, Dirk J, Kapusta, Livia, Wevers, Ron A, Zucker, Nili, Lammens, Martin, Absmanner, Birgit, Morava, Eva, van den Akker, Willem M R, Knopf, Carlos, Verrijp, Kiek, Grunewald, Stephanie, Schuurs-Hoeijmakers, Janneke H M, van Bokhoven, Hans, Jóźwiak, Adam, Lorber, Avraham, Riemersma, Moniek, Huijben, Karin, Lehle, Ludwig, Mandel, Hanna   +20 more
core  

Discovery and characterisation of succinate dehydrogenase inhibitor resistance in Plenodomus biglobosus (phoma stem canker of oilseed rape)

Pest Management Science, EarlyView.
SDHI resistance is reported and characterised for the first time in the oilseed rape phoma stem canker pathogen Plenodomus biglobosus (Leptosphaeria biglobosa). We investigate cross‐resistance patterns, associated SDH target‐site mutations, possible fitness costs, and consider the implications for disease and resistance management.
Kevin M King, Jonathan S West
wiley   +1 more source