Results 61 to 70 of about 771,131 (233)

Prediction of the effects of the top 10 synonymous mutations from 26645 SARS-CoV-2 genomes [version 3; peer review: 1 approved, 2 approved with reservations, 3 not approved]

F1000Research
Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had led to a global pandemic since December 2019. SARS-CoV-2 is a single-stranded RNA virus, which mutates at a higher rate.
Boon Zhan Sia, Wan Xin Boon, Chong Han Ng   +2 more
doaj   +1 more source

Single Synonymous Mutations in KRAS Cause Transformed Phenotypes in NIH3T3 Cells.

PLoS ONE, 2016
Synonymous mutations in the KRAS gene are clustered at G12, G13, and G60 in human cancers. We constructed 9 stable NIH3T3 cell lines expressing KRAS, each with one of these synonymous mutations.
Andrew M Waters, Rachel Bagni, Franklin Portugal, James L Hartley   +3 more
doaj   +1 more source

Variation in synonymous evolutionary rates in the SARS-CoV-2 genome

Frontiers in Microbiology, 2023
IntroductionCoronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Influential variants and mutants of this virus continue to emerge, and more effective virus-related information is ...
Qianru Sun, Qianru Sun, Jinfeng Zeng, Jinfeng Zeng, Kang Tang, Kang Tang, Haoyu Long, Haoyu Long, Chi Zhang, Chi Zhang, Jie Zhang, Jie Zhang, Jing Tang, Jing Tang, Yuting Xin, Yuting Xin, Jialu Zheng, Jialu Zheng, Litao Sun, Litao Sun, Siyang Liu, Siyang Liu, Xiangjun Du, Xiangjun Du, Xiangjun Du   +24 more
doaj   +1 more source

Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module

Advanced Science, EarlyView.
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang, Jiale Qi, Lin Wei, Qin Yu, Zhongyuan Liu, Lianyang Bai, Lang Pan   +6 more
wiley   +1 more source

Prediction of the effects of the top 10 synonymous mutations from 26645 SARS-CoV-2 genomes of early pandemic phase [version 4; peer review: 1 approved, 2 approved with reservations, 3 not approved]

F1000Research
Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had led to a global pandemic since December 2019. SARS-CoV-2 is a single-stranded RNA virus, which mutates at a higher rate.
Boon Zhan Sia, Wan Xin Boon, Chong Han Ng   +2 more
doaj   +1 more source

Characteristics of non-synonymous hotspot mutations for spatial analysis.

, 2022
Characteristics of non-synonymous hotspot mutations for spatial analysis.
Nimisha Ghosh (9637889), Indrajit Saha (1561636), Suman Nandi (475081)   +2 more
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Detecting novel genetic variants associated with isoniazid-resistant Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2014
Isoniazid (INH) is a highly effective antibiotic central for the treatment of Mycobacterium tuberculosis (MTB). INH-resistant MTB clinical isolates are frequently mutated in the katG gene and the inhA promoter region, but 10 to 37% of INH-resistant ...
Sandhya Shekar, Zhen Xuan Yeo, Joshua C L Wong, Maurice K L Chan, Danny C T Ong, Pumipat Tongyoo, Sin-Yew Wong, Ann S G Lee   +7 more
doaj   +1 more source

Characteristics of non-synonymous hotspot mutations for temporal analysis.

, 2022
Characteristics of non-synonymous hotspot mutations for temporal analysis.
Nimisha Ghosh (9637889), Indrajit Saha (1561636), Suman Nandi (475081)   +2 more
core   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source