Results 71 to 80 of about 771,131 (233)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Mutation Analysis of NOS1 Exon 18 Polymorphisms with the Risk of Parkinson’s Disease: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Nitric Oxide Synthase 1 (NOS1) has been implicated in Parkinson’s Disease (PD) pathogenesis through its role in neuronal signaling and oxidative stress.
Gurushantappa S Kadakol, Bhushan B Kulkarni, Ashwini Hiremath   +2 more
doaj   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

Information Entropy of Influenza A Segment 7

Entropy, 2008
Information entropy (H) is a measure of uncertainty at each position within in a sequence of nucleotides.H was used to characterize a set of influenza A segment 7 nucleotide sequences. Nucleotide locations of high entropy were identified near the 5’
Joel K. Weltman, Shaohua Fan, William A. Thompson   +2 more
doaj   +1 more source

Non-synonymous SQSTM1 mutations.

, 2016
Non-synonymous SQSTM1 mutations.
Young H. Kwon (2824823), Wallace L. M. Alward (387966), Todd E. Scheetz (205742), Frances Solivan-Timpe (2824826), Kathy Miller (2824817), Edwin M. Stone (129407), John H. Fingert (129391), Ben R. Roos (2824814), Adam P. DeLuca (2824820), Kai Wang (21246)   +9 more
core   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source

Novel Genetic Variations in Acute Myeloid Leukemia in Pakistani Population

Frontiers in Genetics, 2020
Acute myeloid leukemia (AML) is a hematological malignancy characterized by clonal expansion of blast cells that exhibit great genetic heterogeneity.
Saba Shahid, Muhammad Shakeel, Saima Siddiqui, Shariq Ahmed, Misha Sohail, Ishtiaq Ahmad Khan, Aiysha Abid, Tahir Shamsi   +7 more
doaj   +1 more source

A Generalizable Framework for Building Executable Domain‐Specific Large Language Models Under Data Scarcity: Demonstration on Semiconductor Technology Computer‐Aided Design Simulation

Advanced Intelligent Systems, EarlyView.
A schema‐first alignment framework builds compact, executable domain‐specific language models under data scarcity. Large‐scale synthetic question‐answer generation instills domain knowledge, and a code‐centric IR‐to‐DPO pipeline aligns generation with tool‐executable syntax.
Di Wang, Zhenhua Wu, Yu Liu, Kai Chang, Shaohua Wu   +4 more
wiley   +1 more source

Ensemble learning-based predictor for driver synonymous mutation with sequence representation.

PLoS Computational Biology
Synonymous mutations, once considered neutral, are now understood to have significant implications for a variety of diseases, particularly cancer. It is indispensable to identify these driver synonymous mutations in human cancers, yet current methods are
Chuanmei Bi, Yong Shi, Junfeng Xia, Zhen Liang, Zhiqiang Wu, Kai Xu, Na Cheng   +6 more
doaj   +1 more source

Polymorphism of E6 and E7 Genes in Human Papillomavirus Types 31 and 33 in Northeast China

Canadian Journal of Infectious Diseases and Medical Microbiology, 2023
Persistent infection with human papillomavirus (HPV) types 31 and 33 is an important causative factor for cervical cancer. The E6/E7 genes are key oncogenes involved in the immortalization and transformation of human epithelial cells.
Miao Yu, Si Wu, Shuang Wang, Changwan Cui, Yiping Lu, Zhengrong Sun   +5 more
doaj   +1 more source