Results 101 to 110 of about 1,974,376 (233)
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis [PDF]
, 2013 Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10−4).International Ibd Genetics Consortium, Salvetti, M, Shaunak, S., Halfpenny C, Comi, Giancarlo,, Cusi, D., Pericak-Vance, M.A., Celius, Elisabeth G.,, Martin, Claes, Christina M. Lill, Kockum, Ingrid, Mannisto, Satu, Manrique, Clara P., Sawcer, SJ, Stewart, Graeme, Agliardi, Cristina, Cree BA, Kronsbein H, Selter, RC, Caillier, Stacy,, Lebrun-Frenay, Christine, Hafler, D, Helga Westerlind, Schaefer, C., Westerlind, H., Martinelli, Vittorio,, Spurkland, Anne, Goris, A., Kendall B, Fontaine, Bertrand,, Leone, M.A., Edkins, Sarah, Lathrop, Mark, Saarela, Janna, Shahi, Tejas S, Cree, BAC, Harley, James,, Hong Quach, Olsson, Tomas, Per Hall, Hafler, David, A, Philip De Jager, Myhr KM, Cordelia Langford, Steve Vucic, Henderson, Paul, Reunanen M, Sawcer, Stephen, Hakonarson, Hakon, Butzkueven, Helmut,, Bomfim, Izaura L, Selter, Rebecca, Ilijas Jelcic, Berthele, A., Wilkins, A, Langford, Cordelia,, Slee, Mark,, Larsson, M., Caillier, Stacy J, Patsopoulos, Nikolaos A, James S. Wiley, Cotsapas, Chris, Bruce A. C. Cree, Galimberti, D, Goris, An, Sospedra, Mireia, Salvetti, M., Manrique CP, Mescheriakova J, Rodegher, M., Kermode, A, Harbo, Hanne F.,, Shah, Tejas, Halfpenny, C., Izaura L. Bomfim, Celius, Elisabeth, David Rog, McCauley J.L., Rogier Hintzen, Shields, Simon,, Kilpatrick, Trevor,, Thorpe, J, Frohlich, Irene, Nicholas, R., Giuseppe Liberatore, Sondergaard, HB, Damotte, Vincent, Harbo, Hanne, Flinstad, Wilson JF, Ticca, Anna,, Vucic S, Thorpe, John, Carpentier, W., Barcellos, Lisa F, Roland Martin, Lycke, Jan, Anu Kemppinen, Sorensen PS, Zajicek, J., Gieger C, Stephen L. Hauser, Larsson, Malin,, Hoshi, Muni, Jagodic, M., Hobart, Jeremy,, Hadjixenofontos, Athena, Brian Kendall, Tienari P, Spencer C, Harbo, Hanne F, Barcellos, LF, Brochet, B., Langford, C, Robertson, N.P., Lycke, Jan,, Alfredsson, Lars, Kermode, Allan, Andrews, R, Sospedra, M, van Duijn, Cornelia,, Hobart, Jeremy, Hemmer, B, Bertrand Fontaine, Salvetti M, Spencer, Chris, International Multiple Sclerosis Genetics Consortium, D'Alfonso, S., Bomfim IL, Hemmer B, Søndergaard, Helle Bach, Chris Spencer, Freeman, Colin, Shields, S, Siffrin, Volker, Martin, Claes,, Lie, Benedicte A.,, Irene Coman, Hellenthal G, Andrews, R., Bomfim, Izaura, Westerlind, Helga, Hunt, S.E., Melissa Sorosina, Martin C, Haines, Jonathan,, Kronsbein, Helena,, Duddy, M., Moutsianas, L., Anderson C, Hintzen, R, Harrower, T, Hoshi, M., Beecham, A.H., Shen L, Thorpe, John,, Konidari, Ioanna,, Colin Freeman, Anne Spurkland, Sundqvist, E, Wilkins, Alastair, Konidari I, Jelčić, I., Finn Sellebjerg, Dubois, Bénédicte, Hemmer, Bernhard,, Soelberg Sorensen, Per,, Hunt, Sarah E, Harbo, Hanne,, Lechner Scott J, Robertson, NP, Price SE, Schaefer, Catherine,, Robberecht, Wim,, Alastair Wilkins, Ban, Maria, Mero, Inger-Lise,, Franke, Andre, Carl Anderson, Hall, Per, Westerlind H, Garrett Hellenthal, Edkins, S, Bernardinelli, L, Jenny Link, Hintzen, R., Siffrin, V., Franke, A, Leppä, V, Mazibrada, G, Wilson, James F, Gourraud, PA, Rodegher, Mariaemma,, Brambilla, Paola, Galimberti, Daniela,, Hoshi, M, Frohlich, I.Y., Konidari, I., Franke A, Halfpenny, C, Mason D, Visser, Elizabeth M, Sandra D'Alfonso, Agliardi, Cristina,, Comi, Giancarlo, Dionysia K. Xifara, Bomfim, Izaura L.,, Spencer, C, Oksenberg, Jorge R, Elovaara I, Graetz C, Bach Sondergaard, Helle,, Paola Brambilla, Hauser SL, Satu Mannisto, Rog, D., Ivinson, AJ, Macciardi, F, di Sapio, Alessia, Bergamaschi, L, Anderson, C, Field J, Spencer, Chris,, Ban, M., McVean, Gil,, Evangelou, Nikos,, Sorosina, M., Quach H, Allan Kermode, Davis, Mary, Booth, David, J, Stewart, G, Elovaara, I., Elisabeth G. Celius, Schnetz-Boutaud, N.C., Jeannette Lechner Scott, Adrian J. Ivinson, Harbo, HF, Beecham AH, Booth, David,, Lee, M.H., Broadley, Simon, Amie Baker, Price, Siân E, Broadley, S, Lycke, J, Binder, Thomas M C.,, Barnaby Fiddes, Baker A, Mariaemma Rodegher, Defer, Gilles,, Robberecht W, Rebecca C. Selter, Hillier, C, Xifara, D.K., Shaunak, S, Wiley, James S.,, Guaschino, C., Selter RC, Guaschino, Clara, Sorosina, Melissa, Hakonarson, H, McCabe, C., Lill, CM, Kemppinen, Anu, Graetz, Christiane,, Guaschino, Clara,, Christopher Halfpenny, Emilie Sundqvist, Bellenguez, Celine, Freeman C, Duddy M, Shields, S., Spencer, C., Oturai, Annette,, Hillert, Jan,, Graham, Andrew, Mason, D, Lechner-Scott, J., Spurkland A, Sorosina, M, Damotte, V, Wilson, James F., Ivinson, Adrian J., (IMSGC), International Multiple Sclerosis Genetics Consortium, Athena Hadjixenofontos, Cosemans, Leentje,, Koivisto, K., Price, S.E., Kemppinen, A, Männistö S, Irina Elovaara, Martinelli Boneschi F, Zipp, Frauke, Cavalla, Paola, Coman, IrÃne, Sundqvist, Emilie, Moutsianas, L, Pericak Vance, MA, Lechner-Scott, J, Stacy J. Caillier, Brambilla, P, McVean G, Shah, Tejas S.,, Laura Bergamaschi, Robert Andrews, Sorosina, Melissa,, Graetz, Christiane, Irene Y. Frohlich, Bernardinelli, Luisa,, Price, Sian E.,, Cristina Agliardi, Nilsson, Petra, Hobart, J, Mescheriakova, J, Martinelli-Boneschi, Filippo,, Shen, Lucy, Kendall, Brian, Brambilla, Paola,, Schnetz-Boutaud, Nathalie C, Compston, Alastair,, Simon Shields, Kendall, B., Hall, G., Korn, T, Mannisto, Satu,, Carpentier, Wassila,, Delgado, Silvia, Coman, I., Nilsson P, Agliardi, C., Oksenberg, Jorge,, Jelcic, Ilijas, William Camu, Buck, Dorothea, Blackburn, Hannah,, Thijs, Vincent,, Paola Cavalla, Fontaine, B., Zindler, E., Panos Deloukas, Jeremy Hobart, Coman, I, Alizadeh, M., Leone, Maurizio, Nikolaos A. Patsopoulos, Maurizio A. Leone, Wellcome Trust Case Control Consortium 2, Taylor B, James Harley, Shaunak, Sandip, Donnelly, P., Stewart, Graeme,, Fredrik Piehl, Deloukas, P, Gavin Band, Baranzini, SE, Oksenberg, Jorge R.,, Sondergaard, Helle Bach, Delgado, Silvia R., Coman I, Compston, Alastair, Frohlich, IY, Olsson, T, Lie, BA, Grummel, V., Hillert, Jan, Haines, Jonathan L.,, Barrett, J., Cournu Rebeix I, Franke, A., Cavalla, Paola,, Buck D, Zipp, Frauke,, Michelle H. Lee, Jochim, Angela,, Jager, P, Dubois, B, Hillier C, Link, J., Sà ̧ndergaard, Helle Bach, Grummel, Verena,, Oksenberg, JR, Brochet, B, Cotsapas, C., Sian E. Price, Saarela, Janna,, Kronsbein, Helena, Lucia Corrado, Donnelly P, Cree, Bruce A. C., Pericak-Vance, Margaret, Deloukas, Panos,, Martin, Roland,, Frohlich IY, Robertson, Neil P, Tienari, P., Tejas S. Shah, Shah TS, McCabe, Cristin, Martinelli V, Ticca, A, Schaefer, Catherine, Zipp F, Barcellos, Lisa F., Sellebjerg F, Bruce Taylor, Sellebjerg, F, Hauser, Stephen, Booth, David, Sarah E. Hunt, Hauser, Stephen L.,, Hintzen, Rogier, Barcellos, L.F., Celius, Elisabeth G., Matti Pirinen, Biberacher V, McVean, Gil, Goris, A, Jagodic, M, Manrique, CP, Kilpatrick, Trevor, Sellebjerg, Finn, Cotsapas C, Ivinson AJ, Sergio E. Baranzini, Sundqvist E, Nicholas, Richard,, Hannah Blackburn, Luisa Bernardinelli, A. Di Sapio, Agliardi C, Lathrop, M, Corrado, Lucia, Cournu-Rebeix, Isabelle, Cree, Bruce, Dilthey, Alexander, T, Baranzini, Sergio E, Rog, David, Manrique, Clara P.,, Thorpe, J., Butzkueven, Helmut, D'Alfonso, S, Martinelli-Boneschi, Filippo, Xifara DK, Strange, Amy,, Giancarlo Comi, Patsopoulos, Nikolaos, Hauser, Stephen L., Reunanen, M, Cosemans, Leentje, Andrew Graham, Brundin, L, Barrett, Jeffrey, Wilson, J.F., Zajicek, J, Leentje Cosemans, van Duijn, Cornelia, Rodegher M, Zindler, Eva,, Männistö, S, Sorensen, P.S., Pericak-Vance, Margaret A., Koivisto, K, Price, Siân, Mehdi Alizadeh, Sawcer, Stephen J., Haines, Jonathan L, Mason, Deborah,, Zindler, E, Moutsianas L, Peter Donnelly, Nilsson, P, Harley, J, Zindler E, Dilthey, Alexander T.,, Shaunak, Sandip,, Daniela Galimberti, Vucic, Strahinja, Hall, P., Sundqvist, E., Lycke, J., Jan Lycke, Freeman, C., Männistö, Satu, Bernhard Hemmer, Langford C, Langford, Cordelia, Manrique, Clara, Cosemans, L, Wim Robberecht, Hunt, Sarah, Mason, D., Caillier SJ, Wilson, James F; id_orcid, Vucic, S, Benedicte A. Lie, Martinelli Boneschi, F, Hauser, Stephen L, Field, Judith, Sawcer, Stephen J.,, McCauley, Jacob L.,, Lebrun Frenay C, Visser, Elizabeth M.,, Mason, Deborah, Oksenberg, Jorge R., Strange A, Wilkins, Alastair,, Camu, W, Catherine Schaefer, Galimberti, D., Amy Strange, Jelčić, I, Ivinson, Adrian, Field, Judith,, Annette Oturai, Band G, Halfpenny, Christopher, Martinelli, Vittorio, Zipp, F, Wilson, James, Mireia Sospedra, Harbo, Hanne F., Donnelly, Peter, Alizadeh, Mehdi, Jochim, Angela, Cusi, Daniele,, Barrett, Jeffrey,, Kemppinen, A., Duddy, Martin,, Taylor, B., McCauley, Jacob L., Grummel, V, Link, J, Pericak-Vance, MA, Mero IL, Dubois, Benedicte,, Koivisto, Keijo,, Compston A, Pirinen, M, Davis, Mary F.,, Celius, EG, Andrews, Robert,, Korn, Thomas, Liberatore G, Piehl F, Strange, A., Slee, M., Lie BA, Hall, Gillian, Cavalla, P, Myhr, Kjell-Morten,, Thomas M. C. Binder, Buck, D., Ivinson, A.J., Taylor, Bruce,, Biberacher, Viola, Gieger, Christian, Fiddes, Barnaby, McCauley, J.L., Hawkins, C, Anderson, C., Shen, L, Larsson, M, Camu, William,, Patsopoulos NA, Hillier, Charles, Dubois, B., Søndergaard HB, Hafler D, Gourraud, P-A, Tienari, Pentti, Salvetti, Marco,, Fiddes, B, Brundin, Lou,, Evangelou, N, Bomfim, IL, Shah, Tejas S, Caillier, Stacy J.,, Sellebjerg, Finn,, Duddy, Martin, Galimberti D, Lars Alfredsson, Cusi, D, Freeman, C, Wiley, James, Andrews, Robert, Loukas Moutsianas, Saarela, J., Frohlich, Irene Y., Winkelmann, J, Sawcer, S.J., Christian Gieger, Angela Jochim, Martin, C, Shields, Simon, Pericak-Vance, Margaret A.,, Harley, James, Hauser, SL, Leone, Maurizio A., Ban M, Pericak Vance MA, Blackburn, H, Bernardinelli L, Per Soelberg Sorensen, Graeme Stewart, De Jager P, Lill, Christina, Piehl, F., Hillert, J, Stewart, G., Hintzen, Rogier,, Wassila Carpentier, Maria Ban, Federica Esposito, Eva Zindler, Zajicek J, Carpentier, Wassila, Binder, Thomas, Macciardi, Fabio,, Lee, MH, Corrado, L., Barcellos LF, Liberatore, Giuseppe, Jan Hillert, Martinelli, V., Fontaine, B, Wilson, JF, De Jager, P., D.M. Cusi, Hamsten A, Zajicek, John,, Martin, R, Timothy Harrower, Gourraud, Pierre-Antoine,, Dilthey, Alexander T., Kronsbein, H, Pirinen, Matti,, Leppa, Virpi,, Kronsbein, H., C. Agliardi, Konidari, I, Schnetz Boutaud, NC, Beecham, A H, Graham, Andrew,, Reunanen, Mauri, Myhr, K-M, Shah, Tejas S., Haines JL, Schnetz-Boutaud, Nathalie C.,, Mccauley, Jacob, Graham, A., Cournu-Rebeix, I, McCabe, Cristin,, Duddy, M, Graham A, van Duijn, Cornelia, M., Oksenberg, Jorge, R, Moutsianas, Loukas,, Bellenguez, C, Andre Franke, Ban, Maria,, Thijs V, Guaschino, C, Gordon Mazibrada, Selter, Rebecca C.,, Ling Shen, Buck, D, van Duijn, C, Celius EG, di Sapio, A., Hafler, David, Gillian Hall, Juliane Winkelmann, Lindén M, Muni Hoshi, Lee, Michelle, Nilsson, Petra,, Lebrun-Frenay, C, Vincent Damotte, Keijo Koivisto, Gourraud, Pierre-Antoine, Baranzini, Sergio E.,, Franke, Andre,, Esposito, F, Cristin Mccabe, Corrado, Lucia,, Jorge R. Oksenberg, Søndergaard, H.B., Galimberti, Daniela, Halfpenny, Christopher,, Nicholas, Richard, Taylor, B, De Jager, P, Kilpatrick T, Vucic, Steve,, Sarah Edkins, Olsson, T., Lycke J, Margaret A. Pericak Vance, Baranzini, Sergio, E, Harbo, H.F., Carpentier, W, Filippo Martinelli Boneschi, Hawkins C, Slee, Mark, Lee, Michelle H., Hunt, Sarah E.,, Cree, B.A.C., Agliardi, C, Compston, A, de Jager, Philip, L, Alfredsson, L, Mary F. Davis, Berthele A, Linden, Magdalena,, Wilkins, A., Oturai A, Chris Cotsapas, Brambilla, P., Martin Duddy, Martin, R., Camu, William, Harley J, Lindén, M, Binder, Thomas M. C., Robberecht, W, An Goris, Lechner-Scott, Jeannette, Donnelly, P, Bomfim, I.L., Patsopoulos, NA, Bellenguez, Céline, Manrique, Clara P, Kendall, B, Rodegher, M, Hillier, C., Lechner Scott, J, Fontaine, Bertrand, Harbo HF, Gieger, C, Piehl, Fredrik, Hall, Per,, Butzkueven H, Gourraud PA, Nathalie C. Schnetz Boutaud, Cusi D, Visser, EM, Fiddes, B., Jel?i?, Ilijas, McCauley, Jacob L, Pirinen, Matti, Graetz, C, van der Linden, M, Saarela J, Hellenthal, Garrett, Shah, TS, Patsopoulos, Nikolaos A., Caillier, SJ, Helle Bach Søndergaard, de Jager, Philip,, Hawkins, Clive, Leppä, V., Hafler, David,, Macciardi, F., Magdalena Linden, Edkins, S., Berthele, A, Alexander T. Dilthey, Clara P. Manrique, Barizzone, N, Sandip Shaunak, Macciardi F, Quach, Hong, Christiane Graetz, Schaefer, C, Barizzone, Nadia,, Grummel V, van Duijn, C., Hoshi, Muni,, Haines, Jonathan L., ?, ?, Elovaara, I, Sospedra, M., Myhr, Kjell-Morten, Sospedra M, Korn T, Duijn, Cornelia, Mescheriakova, Julia,, Hemmer, Bernhard, Delgado, Silvia R.,, Clive Hawkins, Dilthey AT, Hakonarson, H., Hobart, J., Davis, MF, Di Sapio, A, Elovaara, Irina,, Blackburn H, Bergamaschi, L., Taylor, Bruce, Mark Lathrop, Hadjixenofontos A, Bellenguez, C., Berthele, Achim,, Cavalla P, Price, Siân E., Cosemans L, Harrower, T., F Barcellos, Lisa,, Winkelmann, J., Moutsianas, Loukas, Gilles Defer, Binder TM, Robertson, Neil P.,, Schnetz Boutaud NC, Leone, MA, Bernardinelli, Luisa, Christine Lebrun Frenay, Defer, Gilles, Thijs, V, Selter, Rebecca C., Trevor Kilpatrick, Bomfim, Izaura L., Martinelli-Boneschi, F, Thomas Korn, Piehl, F, Quach, H, Tomas Olsson, Donnelly, Peter,, Baranzini, Sergio E., Hawkins, C., Lathrop M, Nagels, G., Julia Mescheriakova, Slee M, Deborah Mason, Selter, Rebecca C, Sawcer SJ, Linden, Magdalena, Cournu Rebeix, I, David Booth, Graham, A, Evangelou, N., Petra Nilsson, Visser, E.M., Stephen J. Sawcer, Esposito, Federica, Stewart G, Barcellos, Lisa, Binder, TMC, Ban, M, Fontaine B, Janna Saarela, Evangelou N, Booth D, Shields S, Leone MA, Sospedra, Mireia,, Westerlind, H, Binder, Thomas MC, Luessi, F., Esposito, Federica,, Leppä V, Mazibrada, Gordon, Broadley S, Lund University., Anders Hamsten, Luessi, Felix,, Mauri Reunanen, Haines, J.L., Ingrid Kockum, Cournu-Rebeix, Isabelle,, Hafler, D., Shaunak S, Slee, M, Schnetz-Boutaud, Nathalie, Lill, Christina M., Deloukas P, Compston, A., Saarela, J, Liberatore, Giuseppe,, Nicholas R, Olsson, Tomas,, Deloukas, P., Rog, D, Robertson NP, Camu, W., Reunanen, M., Xifara, Dionysia, Ashley H. Beecham, Ticca, Anna, Tienari, P, Jochim, A., Biberacher, V., Selter, R.C., Martinelli, V, Brundin, Lou, Binder, Thomas M C, Felix Luessi, DAlfonso, Sandra,, di Sapio, Alessia,, Mazibrada G, Sorensen, PS, Schaefer C, Xifara, D K, Hobart J, Baker, A., Caillier, Stacy, J, Goris, An,, Band, G., Luessi, Felix, Larsson M, Goris A, D'Alfonso, Sandra, Sundqvist, Emilie,, Band, Gavin, Caillier, Stacy J., Strange, A, Quach, H., Bergamaschi, Laura, Bergamaschi, Laura,, Jagodic, Maja, Price, Sian E., Schnetz-Boutaud, NC, Deloukas, Panos, Grummel, Verena, Thijs, Vincent, Frohlich, Irene Y.,, John Zajicek, Barrett, J, Anderson, Carl, Vittorio Martinelli, Hintzen R, Shen, Ling, Hellenthal, G, Damotte V, Sorensen, Per Soelberg, Defer G, Jochim, A, Wilson, James F.,, Alfredsson L, Alfredsson, L., Winkelmann, Juliane,, Mark Slee, Band, G, Winkelmann J, McVean, G, Carpentier W, McCabe C, Mazibrada, Gordon,, Graetz, C., Link, Jenny, Delgado, Silvia R, Alastair Compston, Nilsson, P., Cree, Bruce A C, Jonathan L. Haines, Pierre Antoine Gourraud, Binder, TM, Elizabeth M. Visser, Mescheriakova, Julia, Hamsten, A, Lindén, Magdalena, Wiley, James S., Hillier, Charles,, Barrett J, Band, Gavin,, Isabelle Cournu Rebeix, Korn, Thomas,, Beecham, Ashley H, Tienari, Pentti,, Beecham, AH, Cree, Bruce A C.,, Davis, Mary F, Comi G, De Jager, Philip, Leone, Maurizio A, Ivinson, Adrian J.,, Coman, Irene, Myhr, KM, Larsson, Malin, Siffrin, V, McCabe, C, Hauser, S.L., Xifara, Dionysia K., Harrower, Timothy,, Nagels G, Kemppinen, Anu,, Hawkins, Clive,, Hall, P, Jochim A, Harley, J., Baker, Amie, Xifara, DK, Edkins, Sarah,, Shen, Ling,, Davis MF, Hanne F. Harbo, Hakonarson, Hakon,, Esposito, F. +999 morecore +1 more sourceAssociation of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing.
PLoS ONE, 2012 BackgroundRecent genome-wide association studies (GWAS) have identified common variants in the UMOD region associated with kidney function and disease in the general population.Anna Köttgen, Qiong Yang, Lawrence C Shimmin, Adrienne Tin, Céline Schaeffer, Josef Coresh, Xuan Liu, Luca Rampoldi, Shih-Jen Hwang, Eric Boerwinkle, James E Hixson, W H Linda Kao, Caroline S Fox +12 moredoaj +1 more sourceThe Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit
Advanced Science, EarlyView.This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu +9 morewiley +1 more sourceOvercoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min +10 morewiley +1 more sourceRare non-synonymous variants of HsIFNλ4 affect antiviral activity.
, 2018 (A) Ancestry-based localization and frequency of human non-synonymous variants of HsIFNλ4 in African (AFR), South Asian (SAS), East Asian (EAS), European (EUR) and American (AMR) populations within the 1000 Genomes Database.Daniel Mair (5849150), Sarah A. Tishkoff (168614), Elihu Aranday-Cortes (107610), Swathi Sukumar (5849147), Shaohua Fan (3265251), Ana da Silva Filipe (5849153), Connor G. G. Bamford (5849141), John McLauchlan (425839), Juan L. Mendoza (5849156), Ines Cordeiro Filipe (5849144), K. Christopher Garcia (256413) +10 morecore +1 more sourceSwitching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants
Advanced Science, EarlyView.Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer +17 morewiley +1 more source
