Results 81 to 90 of about 1,974,376 (233)

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Genetic variants analysis of three dromedary camels using whole genome sequencing data. [PDF]

PLoS ONE, 2018
Whole genome wide identification and annotation of genetic variations in camels is in its first steps. The aim of this study was the identification of genome wide variants, functional annotations of them and enrichment analysis of affected genes using ...
Reza Khalkhali-Evrigh, Seyed Hasan Hafezian, Nemat Hedayat-Evrigh, Ayoub Farhadi, Mohammad Reza Bakhtiarizadeh   +4 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing

Journal of the Endocrine Society, 2018
Primary adrenal insufficiency (PAI) is a potentially life-threatening condition that can present with nonspecific features and can be difficult to diagnose.
A. Maharaj, Federica Buonocore, E. Meimaridou, G. Ruiz-Babot, L. Guasti, Hwei-Ming Peng, Cameron P Capper, Neikelyn Burgos-Tirado, R. Prasad, C. Hughes, Ashwini Maudhoo, E. Crowne, T. Cheetham, C. Brain, Jenifer P. Suntharalingham, Niccolò Striglioni, B. Yuksel, F. Gurbuz, Sangay Gupta, R. Lindsay, R. Couch, H. Spoudeas, T. Guran, S. Johnson, D. Fowler, L. Conwell, A. McInerney-Leo, D. Drui, B. Cariou, J. López-Siguero, M. Harris, E. Duncan, P. Hindmarsh, R. Auchus, M. Donaldson, J. Achermann, L. Metherell   +36 more
semanticscholar   +1 more source

Case-control analysis on non-synonymous PALB2 variants.

, 2014
Case-control analysis on non-synonymous PALB2 variants.
Mai Xu (344558), Michael Kovacs (580924), Lauren G. Aoude (200062), Grant W. Montgomery (131518), Jeffrey M. Trent (135617), Peter Johansson (64440), Nicholas G. Martin (113568), Kevin M. Brown (182605), Jane M. Palmer (580925), Nicholas K. Hayward (35609), Zhen Zhen Zhao (271884), Judith Symmons (580926)   +11 more
core   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Forecasting framework for dominant SARS-CoV-2 strains before clade replacement using phylogeny-informed genetic distances

Frontiers in Microbiology
IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the global coronavirus disease 2019 (COVID-19) pandemic and continues to drive successive waves of infection through the emergence of novel variants ...
Kyuyoung Lee, Atanas V. Demirev, Sangyi Lee, Seunghye Cho, Hyunbeen Kim, Junhyung Cho, Jeong-Sun Yang, Kyung-Chang Kim, Joo-Yeon Lee, Woojin Shin, Soyoung Lee, Sejik Park, Philippe Lemey, Man-Seong Park, Man-Seong Park, Man-Seong Park, Jin Il Kim, Jin Il Kim, Jin Il Kim   +18 more
doaj   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Identification of rare non-synonymous variants in SYNE1/CPG2 in bipolar affective disorder

Psychiatric Genetics, 2017
Background Bipolar affective disorder (BPD) is a severe mood disorder with a prevalence of ∼1.5% in the population. The pathogenesis of BPD is poorly understood; however, a strong heritable component has been identified.
S. Sharp, Jenny Lange, Radhika Kandaswamy, Mazen Daher, A. Anjorin, N. Bass, A. McQuillin   +6 more
semanticscholar   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source