Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. [PDF]
, 2002 We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFkappaB activation and collagenase-1 (CL-1)/matrix ...
Werb, Zena, Werner, Erica
core
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang +10 more
wiley +1 more source
New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases. [PDF]
Int J Mol Sci, 2021 de Seny D +12 more
europepmc +1 more source
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose This registry study aimed to evaluate the safety and effectiveness of collagen membrane‐covered matrix‐associated autologous chondrocyte implantation (cMACI) versus periosteum‐covered MACI (pMACI) for large knee cartilage defects (Outerbridge III–IV, ≥4 cm²) in the femorotibial and/or patellofemoral joints with a minimum 2‐year follow ...
Yuji Uchio +4 more
wiley +1 more source
Infrapatellar Fat Pad-Synovial Membrane Anatomo-Fuctional Unit: Microscopic Basis for Piezo1/2 Mechanosensors Involvement in Osteoarthritis Pain. [PDF]
Front Cell Dev Biol, 2022 Emmi A +10 more
europepmc +1 more source
A retrospective study on 195 horses with contaminated and infected synovial cavities [PDF]
, 2009 This study analyzes the clinical aspects of contaminated and infected synovial cavities in horses and evaluates their prognosis after treatment. The medical records of 195 affected horses referred between June 1999 and July 2004 were reviewed. Twenty-six
Dewulf, Jeroen +5 more
core +1 more source
Punch Biopsy of Synovial Membrane [PDF]
Annals of the Rheumatic Diseases, 1951 H F, POLLEY, W H, BICKEL
openaire +2 more sources
Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
Med Research, EarlyView.The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source
Production of Cytotoxic Antibodies After Intra-Articular Injection of Allogeneic Synovial Membrane Mesenchymal Stem Cells With and Without LPS Administration. [PDF]
Front Immunol, 2022 Rosa GDS +9 more
europepmc +1 more source
Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. [PDF]
, 2010 IntroductionThe interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects
Adamopoulos, Iannis E +7 more
core +1 more source