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Iguratimod in combination with conventional therapy suppresses inflammation and improves joint structure and function in rheumatoid arthritis. [PDF]

Am J Transl Res
Liu S, Jiang K, Yu J, Ge J, Wang T, Nie J, Cao W.   +6 more
europepmc   +1 more source

Novel insights into the biology of childhood arthritis- lessons learned from the synovium. [PDF]

Arthritis Res Ther
Bolton C, Chang MH.
europepmc   +1 more source

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Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis.

ACS Nano, 2022
Synovial fibroblasts in rheumatoid arthritis (RA) joints mediate synovial hyperplasia, progressive joint destruction, and the potential spread of disease between joints by producing multiple pathogenic proteins.
C. Deng, Xuan Zhao, Yuxiao Chen, K. Ai, Yuqing Zhang, T. Gong, C. Zeng, Guanghua Lei   +7 more
semanticscholar   +1 more source

Synovial Membrane Punch Biopsy

Archives of Internal Medicine, 1961
Biopsy material has proved to be of value in the investigation of many inflammatory and malignant disease processes. Examination of the synovial membrane by open biopsy, under anesthesia, has been performed by orthopedists for many years. Polley and Bickel, in 1951, 1,2 described an instrument for performing a closed punch biopsy.
S, SCHWARTZ, N, COOPER
openaire   +2 more sources

Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome

Advances in Materials, 2022
Osteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its progression is closely associated with an imbalance in M1/M2 synovial macrophages. Repolarizing pro‐inflammatory M1 macrophages into the anti‐inflammatory M2 phenotype
Lei Zhang, Xiang Chen, Pingqiang Cai, Han Sun, Siyu Shen, Baosheng Guo, Qing Jiang   +6 more
semanticscholar   +1 more source

Hemangioma of the Synovial Membrane

The Journal of Bone & Joint Surgery, 1959
Eleven patients with hemangioma of the synovial membrane have been seen at the Mayo Clinic from 1907 through 1956. The tumor occurred in the knee in nine patients, and in the ankle and elbow, respectively, in two others. These patients represent the first reported instances of involvement of these joints. The results of this study suggest that synovial
R C, LEWIS, M B, COVENTRY, E H, SOULE
openaire   +2 more sources

Fibroblast‐like synoviocytes: Role in synovial fibrosis associated with osteoarthritis

Wound Repair and Regeneration, 2021
The synovial membrane undergoes a variety of structural changes throughout the pathogenesis of osteoarthritis (OA), including the development of fibrosis.
A. Maglaviceanu, B. Wu, M. Kapoor
semanticscholar   +1 more source

Regulation of Synovial Macrophages Polarization by Mimicking Efferocytosis for Therapy of Osteoarthritis

Advanced Functional Materials, 2022
The progression of osteoarthritis is associated with chronic synovitis caused by synovial macrophage infiltration and proinflammatory M1 polarization. Accordingly, repolarization of macrophages from the M1 to M2 phenotype by nanoagents is proposed as a ...
Hongbin Yang, Zhenyan Yu, Shuaishuai Ji, Jie Yan, Yan Kong, Q. Huo, Zhijun Zhang, Yimin Niu, Yang Liu   +8 more
semanticscholar   +1 more source