Results 31 to 40 of about 17,376 (193)
Advanced Science, EarlyView.We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong +11 more
wiley +1 more source
Ortadoğu Tıp Dergisi, 2020 The paper describes the case of a 60-year-old male patient with a mass in the left jugulodigastric area, which was later identified as synovial sarcoma. Differential diagnoses such as cystic lesions, metastatic lymph nodes, and salivary gland tumors were considered.
Emre Emekli +3 more
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Advanced Science, EarlyView.A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao +34 more
wiley +1 more source
How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU
British Journal of Clinical Pharmacology, EarlyView.The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley +1 more source
Clinical Advances in Periodontics, EarlyView.Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal +8 more
wiley +1 more source
Biphasic synovial sarcomas of the liver: a case report and literature review
Diagnostic Pathology, 2022 Background Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities.
Defeng Liang +4 more
doaj +1 more source
Synovial sarcoma: the misdiagnosed sarcoma
EFORT Open ReviewsSynovial sarcoma is a rare and highly malignant soft tissue sarcoma. The inconspicuous and diversity of its early symptoms make it a highly misdiagnosed disease. The management of synovial sarcomas is challenging as
Chengxiang Li +4 more
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Indian Pediatrics, 2016 Malignant tumors in neonates are rare.A tumor was detected in the left biceps of a 3-day old neonate. Tumor biopsy and molecular study confirmed the diagnosis of synovial sarcoma. The child received multi-modality treatment with surgery and chemotherapy.The child is disease-free on follow-up period of 12 months.Synovial sarcoma can rarely occur in a ...
Venkatraman, Radhakrishnan +3 more
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Journal of Surgical Oncology, EarlyView.ABSTRACT Background Text‐based pathology reports inadequately communicate complex three‐dimensional (3D) relationships in musculoskeletal oncology, potentially contributing to errors in re‐resection and adjuvant treatment planning. While our prior 7‐case pilot study established technical feasibility, the scalability of this workflow and its utility as ...
Riley S. Gilbertson +11 more
wiley +1 more source
Primary Renal Synovial Sarcoma
Case Reports in Urology, 2011 Synovial sarcomas are generally deep-seated tumors that most often occur in the proximity of large joints of adolescents and young adults. We describe two cases of primary renal synovial sarcoma that were treated successfully by radical nephrectomy ...
Mehmet Gulum +7 more
doaj +1 more source