Results 191 to 200 of about 9,706,454 (336)

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Cholesterol and steroid synthesis pathways may be involved in the inhibition of osteosarcoma cell viability by calcium-sensing receptor antagonism. [PDF]

PeerJ
Wang L, Wang J, Chu X, Liu Y, Fan Y, Qi X, Guo J, Wang S.   +7 more
europepmc   +1 more source

A polyoxometalate cluster-based single-atom catalyst for NH₃ synthesis via an enzymatic mechanism

, 2021
Shamraiz Hussain Talib, Xiaohu Yu, Zhansheng Lu, Khalil Ahmad, Tongtong Yang, Hai Xiao, Jun Li   +6 more
openalex   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Recent advancements in the synthesis of <i>Veratrum</i> alkaloids. [PDF]

Beilstein J Org Chem
Mögel M, Berger D, Heretsch P.
europepmc   +1 more source

High‐Throughput Miniaturized Synthesis of PROTAC‐Like Molecules [PDF]

Ye Tian, Maximilian Seifermann, Liana Bauer, Charlotte Luchena, Janne J. Wiedmann, S. Schmidt, Alexander Geisel, Sergii Afonin, Julius Höpfner, Marius Brehm, Xinyong Liu, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +13 more
openalex   +1 more source

Synthesis / Synthesis

, 2017
openaire   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Text-mined dataset of solid-state syntheses with impurity phases using Large Language Model. [PDF]

Sci Data
Lee S, Cruse K, Baibakova V, Ceder G, Jain A.   +4 more
europepmc   +1 more source