Results 141 to 150 of about 1,905,493 (317)
Synthetic receptors for ammonium ions using dynamic combinatorial chemistry [PDF]
, 2015 The general topic of this dissertation is the development of synthetic receptors for organic ammonium ions in near physiological conditions using disulfide dynamic combinatorial chemistry (DCC).
Hamieh, Saleh
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Modern inorganic synthetic chemistry /
Includes index.Online resource; title from PDF title page (ScienceDirect, viewed February 24, 2017).Front Cover; Modern Inorganic Synthetic Chemistry; Modern Inorganic Synthetic Chemistry; Copyright; Contents; List of Contributors; Preface to the Second ...
Xu, Yan,editor., Xu, Ruren,editor.
core
, 1999 A printed bowtie antenna for a Post Reception Synthetic Focussing Surface Penetrating Radar (PRSF-SPR) has been developed with the aid of FDTD analysis.
Nilavalan, R, Benjamin, R, Hilton, GS
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Noise Reduction Using Synthetic Microjet Excitation in Supersonic Rectangular Jets
Applied SciencesThis work explores a potential methodology for rectangular jet noise reduction that employs nozzle unsteady microjet excitation. Using high-fidelity computational studies and spectral analyses, major jet noise sources impacted by the applied actuation ...
Michael Marques +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Policy and research : lessons from the Clackmannanshire synthetic phonics initiative
, 2009 This article explores why policy makers in England and Scotland responded so differently to the Clackmannanshire study on synthetic phonics. It suggests that a deeper understanding of the national and local policy contexts can explain Scotland's response.
Ellis, Sue
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source