Results 121 to 130 of about 3,358,432 (297)

Synthetic Control

Kobunshi, 1980
Abstract In the preceding chapters, I described our main efforts devoted to the development of new methods for bond formations, such as carbon-carbon bonds, amide and phosphate linkages, etc. At that time, the accumulation of experience within our group, along with rapid progress in synthetic organic chemistry, led me to believe that the
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Synthetic cannabinoids [PDF]

Canadian Medical Association Journal, 2013
Tony, Antoniou, David N, Juurlink
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Toulmin’s “Analytic Arguments”

Informal Logic, 2012
Toulmin’s formulation of “analytic arguments” in his 1958 book, The Uses of Argument, is opaque. Commentators have not adequately explicated this formulation, though Toulmin called it a “key” and “crucial” concept for his model of argument ...
Ben Hamby
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

On Synthetic Life [PDF]

, 2001
Orsi, Michael P.
core   +2 more sources

A Behavioral Confirmation and Reduction of the Natural versus Synthetic Drug Bias

, 2019
Research reveals a biased preference for natural versus synthetic drugs; however, this research is based upon self-report and has not examined ways to reduce the bias. We examined these issues in five studies involving 1,125 participants.
Dillard, Amanda J., Lappas, Courtney M., Meier, Brian P., Osorio, Eric S.   +3 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Noise Reduction Using Synthetic Microjet Excitation in Supersonic Rectangular Jets

Applied Sciences
This work explores a potential methodology for rectangular jet noise reduction that employs nozzle unsteady microjet excitation. Using high-fidelity computational studies and spectral analyses, major jet noise sources impacted by the applied actuation ...
Michael Marques, Surabhi Singh, Anastasios Lyrintzis, Vladimir Golubev   +3 more
doaj   +1 more source