Results 121 to 130 of about 2,952,613 (401)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Exosome-Mediated Chemoresistance in Cancers: Mechanisms, Therapeutic Implications, and Future Directions

Biomolecules
Chemotherapy resistance represents a formidable obstacle in oncological therapeutics, substantially compromising the efficacy of adjuvant chemotherapy regimens and contributing to unfavorable clinical prognoses.
Gengqi Liu, Jingang Liu, Silu Li, Yumiao Zhang, Ren He   +4 more
doaj   +1 more source

Encryption and steganography of synthetic gene circuits

Nature Communications, 2018
Artificial gene circuits represent intellectual property that under some circumstances may need to be obfuscated to prevent discovery by third parties. Here the authors use encryption by overlapping recombinase sites and steganography by the introduction
Oliver Purcell, Jerry Wang, Piro Siuti, Timothy K. Lu   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Synthetic biology: Understanding biological design from synthetic circuits [PDF]

, 2009
An important aim of synthetic biology is to uncover the design principles of natural biological systems through the rational design of gene and protein circuits.
A Becskei, A Becskei, A Becskei, A Friedland, A Kinkhabwala, A Levskaya, A Raj, A Raj, A Remenyi, A Wagner, AE Tsong, Alexander van Oudenaarden, B Kornmann, B Suess, BJ Yeh, BN Armbruster, BP Prud'homme, C Dugave, C Grilly, C Khosla, CC Guet, CH Martin, CJ Bashor, CL Beisel, D Grate, D Ro, D Rothlisberger, DD Young, DE Nelson, E Fung, E Ozbudak, E Segal, EA Davidson, ED Conrad, EH Davidson, EJ Steen, EM Ozbudak, ES Gilbert, F Jacob, FG Cruz, FJ Isaacs, FJ Isaacs, FK Balagadde, G Werstruck, I Cantone, I Golding, IA Swinburne, J Gerhart, J Gertz, J Gore, J Hasty, J Janin, J Kaplan, J Pedraza, J Stricker, JA Ubersax, JC Anderson, JE Dueber, JM Skerker, JR Pomerening, JR Pomerening, JS Chuang, JS Mattick, JT Bridgham, JT Mettetal, K Brenner, K Hammer, K Harris, K Tatebayashi, L Cai, L You, M Acar, M Behar, M Isalan, M Isalan, M Proft, M Rajendran, M Rapp, M Tigges, M-T Chen, MB Elowitz, MB Elowitz, MN McClean, MN Win, MR Atkinson, MS Antunes, N Geva-Zatorsky, N Rosenfeld, N Rosenfeld, NE Buchler, O Kwon, P Cironi, P Hersen, PL Howard, RJ Taylor, RP Bhattacharyya, RS Cox, S Basu, S Basu, S Hooshangi, S Pokharel, S Shimizu-Sato, SB Cambridge, Shankar Mukherji, SK Desai, T Bulter, T Ellis, TL Deans, TY Tsai, U Alon, Y Setty, Y Tanouchi, YT Maeda, Z Waks   +113 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inducible chromosomal rearrangement reveals nonlinear polygenic dosage effects in driving aneuploid yeast traits

Nature Communications
Aneuploidy induces chromosomal scale alterations in gene dosage, impacting organismal proliferation yet serving as a driver for adaptive evolution.
Hongyi Yin, Zhou Guo, Chu Zhou, Lu Ma, Yi Wu, Ying-jin Yuan   +5 more
doaj   +1 more source

In the Age of Synthetic Biology, Will Antimicrobial Peptides be the Next Generation of Antibiotics? [PDF]

, 2020
Félix Jaumaux, Luz P. Gómez de Cadiñanos, Philippe Gabant   +2 more
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

2003 Synthetic Biology study [PDF]

, 2007
This is the final report of the 2002-2003 synthetic biology study, which brought together ~50 researchers to discuss an improved framework for engineering biology.
Endy, Drew
core