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Biochemistry, 2019
With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied ...
Jens Nielsen +4 more
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With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied ...
Jens Nielsen +4 more
openaire +3 more sources
The limits of synthetic biology
Trends in Biotechnology, 2015The pioneering works of Watson, Crick, Wilkins, and Franklin [1,2] on the structure of DNA have captivated our imaginations for over half a century and continue to shape our future endeavors. The genetic code, a mystery for many years, was soon thereafter decoded by organic chemists employing organic synthesis of polynucleotides [3].
Peter A. Carr, Bijan Zakeri
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Synthetic biology and healthcare
Emerging Topics in Life Sciences, 2019Through the application of the engineering paradigm of ‘design–build–test–learn’ allied to recent advances in DNA sequencing, bioinformatics and, critically, the falling cost of DNA synthesis, Synthetic Biology promises to make existing therapies more accessible and be at the centre of the development of new types of advanced therapies.
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Synthetic Biology and Darwinism
2014Synthetic biology is an emerging transdisciplinary approach that combines tools from engineering, computer and information sciences with biotechnological methods, in order to study and transform living beings. It addresses questions that span from essential characteristics of life to sophisticated modifications of -mostly- micro-organisms in relation ...
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That Was the Synthetic Biology That Was
2009Visions of a synthetic engineering-based approach to biology have been a prominent and recurring theme in the history of biology in the twentieth century. Several major moments in this earlier history of attempts to redesign life are discussed: the turn-of-the-century prominence of experimental evolution and the coining of “synthetic biology” in 1912 ...
Luis Campos, Luis Campos
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Trends in Biotechnology, 2015
Synthetic biology has eluded precise definition since its early days at the turn of the 21st century. At its heart are the goal of engineering biology to control living systems and the practice of assembling a synthetic system from component parts. However, the boundaries of synthetic biology as a discipline are hazy.
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Synthetic biology has eluded precise definition since its early days at the turn of the 21st century. At its heart are the goal of engineering biology to control living systems and the practice of assembling a synthetic system from component parts. However, the boundaries of synthetic biology as a discipline are hazy.
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ACS Synthetic Biology, 2013
Synthetic biology is frequently defined as the application of engineering design principles to biology. Such principles are intended to streamline the practice of biological engineering, to shorten the time required to design, build, and test synthetic gene networks. This streamlining of iterative design cycles can facilitate the future construction of
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Synthetic biology is frequently defined as the application of engineering design principles to biology. Such principles are intended to streamline the practice of biological engineering, to shorten the time required to design, build, and test synthetic gene networks. This streamlining of iterative design cycles can facilitate the future construction of
openaire +2 more sources
Current Opinion in Biotechnology, 2001
Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes ...
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Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes ...
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The promise of synthetic biology
Applied Microbiology and Biotechnology, 2006DNA synthesis has become one of the technological bases of a new concept in biology: synthetic biology. The vision of synthetic biology is a systematic, hierarchical design of artificial, biology-inspired systems using robust, standardized, and well-characterized building blocks.
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