Results 171 to 180 of about 25,449,411 (299)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Scaling Up Forest Vision with Synthetic Data. [PDF]

Int J Comput Vis
She Y, Blake A, Coomes D, Keshav S.
europepmc   +1 more source

Synthetic data in medical research

BMJ Medicine, 2022
Theodora Kokosi, Katie Harron
openaire   +4 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Ministry of Justice Synthetic Data First Family Court, England and Wales, 2011-2023

copyright UK Data Service and data collection copyright owner.The Ministry of Justice (MoJ) Data First Synthetic Data Project aims to improve engagement with Data First datasets by making synthetic versions of content available to enable more rapid ...
Ministry of Justice
core   +1 more source

Evaluating the quality of tabular synthetic data in health care. [PDF]

PLOS Digit Health
Nanevski I, Mohebi M, Jäger S, Otte K, Prasser F, Schulte-Althoff M, Fürstenau D, Biessmann F.   +7 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Addressing the Challenges in Using Synthetic Data for Health Research: Application to Cardiology. [PDF]

JMIR Cardio
Baschet L, Marque S, Locret S, Jenssen J, Barbet V, Jourdain P.   +5 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Robust Cell Segmentation for Size Distribution Estimation via Synthetic-Data Training. [PDF]

Biotechnol J
Kim HB, Lee C, Lee N, Han H, Park C, Hong MS.   +5 more
europepmc   +1 more source