Results 151 to 160 of about 4,015,932 (307)

Vitamin B12: A Comprehensive Review of Natural vs Synthetic Forms of Consumption and Supplementation. [PDF]

Cureus
Behringer CR, Kulkarni A, Weinstein A.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Synthetic Phenomenology

, 2009
The term "synthetic phenomenology" refers to: 1) any attempt to characterize the phenomenal states possessed, or modeled by, an artefact (such as a robot); or 2) any attempt to use an artefact to help specify phenomenal states (independently of whether ...
Ron Chrisley (4460344)
core   +1 more source

Synthetic Forms Most Beautiful: Engineering Insights into Self-Organization. [PDF]

Physiology (Bethesda)
Xu Z, Chang CC, Coyle SM.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Naturally Derived Versus Synthetic Salicylic Acid: Physicochemical Properties, Transdermal Permeation and Macrophage Immunomodulation. [PDF]

Antioxidants (Basel)
Camlik G, Altay Benetti A, Ozokan G, Erdogan Uzunoglu U, Macit M, Turkoz Acar E, Tas C, Degim IT.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Technology: Chevron, GNC project described

, 1983
journal articleThe Chevron and GNC Energy Corporation\u27s Sunny side Tar Sands Project will produce 34,675 barrels per operating day of 35°API gravity synthetic crude oil from 37 million tons per year of tar sands ore with an average bitumen content of ...

core  

Reconsidering Mineral Formulations in Human Health and Disease: Molecular Mechanisms, Bioavailability and Metabolic Fates. [PDF]

Int J Mol Sci
Ye M, Rhie SJ, Park Y, Kim W, Shim I.
europepmc   +1 more source