Results 71 to 80 of about 4,015,932 (307)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Effects of the high-molecular excipients on optimization of the pharmacokinetic properties of drugs
Фармакокинетика и Фармакодинамика, 2020 Applying of different natural and synthetic excipients as in developing of drug forms as manufacturing various drug delivery systems was shown.
P. . Bochkov +4 more
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Molecular recognition of surface-immobilized carbohydrates by a synthetic lectin
Beilstein Journal of Organic Chemistry, 2014 The molecular recognition of carbohydrates and proteins mediates a wide range of physiological processes and the development of synthetic carbohydrate receptors (“synthetic lectins”) constitutes a key advance in biomedical technology.
Melanie Rauschenberg +4 more
doaj +1 more source
Beyond natural: synthetic expansions of botanical form and function [PDF]
New Phytologist, 2020 SummaryPowered by developments that enabled genome‐scale investigations, systems biology emerged as a field aiming to understand how phenotypes emerge from network functions. These advances fuelled a new engineering discipline focussed on synthetic reconstructions of complex biological systems with the goal of predictable rational design and control ...
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Texas Real Estate Forms Manual: Third Edition, Volume 3
, 2017 Third volume of a manual compiled by professional lawyers in the state of Texas regarding the processes and forms needed for typical real estate transactions.
State Bar of Texas. Real Estate Forms Committee.
core
yy6linda/synthetic-ehr-benchmarking: v1.0.0
, 2022 <p><strong>Full Changelog</strong>: <a href="https://github.com/yy6linda/synthetic-ehr-benchmarking/commits/v1.0.0">https://github.com/yy6linda/synthetic-ehr-benchmarking/commits/v1.0.0</a></p ...
yy6linda +3 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source