Results 91 to 100 of about 2,603,336 (302)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A bi-level advanced control framework for large-scale control of buildings with system-level impact
Energy and AIIncreased electricity consumption combined with new forms of generation is testing the reliability of our grid infrastructure. This work describes a method to improve the reliability of the grid through large-scale advanced building control.
Dylan Wald +9 more
doaj +1 more source
Towards a System Level Reliability Approach for Solid State Lighting
Journal of Light & Visual Environment, 2011 Solid State Lighting applications are slowly but gradually pervading into our daily life. A Solid State Lighting system is composed of a LED engine with a micro-electronic driver(s) in a housing that also supplies the optic design. Knowledge of system level reliability is crucial for the business success of future Solid State Lighting (SSL) systems ...
Willem D. van DRIEL +2 more
openaire +2 more sources
Safer clinical systems : interim report, August 2010 [PDF]
, 2010 Safer Clinical Systems is the Health Foundation’s new five year programme of work to test and demonstrate ways to improve healthcare systems and processes, to develop safer systems that improve patient safety.
Cooke, Matthew (Professor of clinical systems design) +1 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Jixie qiangduIn order to ensure the industrial robot realizes the reliability goal, reliability allocation is a task to be accomplished in its manufacturing design stage.
XU Minjun +5 more
doaj
Maintaining the reliability of agricultural machinery in the complex of developing an engineering and technical system [PDF]
BIO Web of ConferencesThe increase in the reliability of agricultural machinery is ensured by the efficiency of the machine repair and maintenance system and the engineering and technical service of the agro-industrial complex, which meets the requirements of progressive ...
Kataev Yuri +2 more
doaj +1 more source