Results 81 to 90 of about 2,603,336 (302)

Using New Camera-Based Technologies for Gait Analysis in Older Adults in Comparison to the Established GAITRite System [PDF]

open access: yes, 2019
Various gait parameters can be used to assess the risk of falling in older adults. However, the state-of-the-art systems used to quantify gait parameters often come with high costs as well as training and space requirements.
Mansow-Model, Sebastian   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Bayesian sequential estimation of the reliability of a parallel-series system

open access: yes, 2012
We give a risk-averse solution to the problem of estimating the reliability of a parallel-series system. We adopt a beta-binomial model for components reliabilities, and assume that the total sample size for the experience is fixed.
Benkamra   +12 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

矿用自卸车轮边行星传动机构模糊可靠性优化

open access: yesJixie chuandong, 2014
With a purpose of the minimum gear tooth width and the smallest planetary gear train volume,a fuzzy reliability of system-level optimization method is proposed to solve problems of the short life and insufficient flexibility of electric wheel planetary ...
罗天洪, 江礁, 罗文军, 林超
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Bayesian Network‐Based Uncertainty Quantification of Ship Isolation System Using Multi‐Level Data

open access: yesEngineering Reports
The shock response of ship isolation systems is directly related to the safety of gas turbines and associated equipment. However, due to the high complexity of system‐level shock testing, existing experimental data are sparse and highly scattered, posing
Rongqiao Wang   +7 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Research on Reliability Allocation Method for Traction Power Supply System of Electrified Railways in Mountainous Areas

open access: yesIEEE Access
The electrified railways in mountainous areas are faced with multiple difficulties such as weak power grids, special climatic environments, complex and dangerous geographical conditions, which poses a great challenge to the reliable power supply of the ...
Like Pan   +4 more
doaj   +1 more source

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