Results 131 to 140 of about 40,752,794 (367)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Fiscal Volatility Shocks and Economic Activity [PDF]
We study the effects of changes in uncertainty about future fiscal policy on aggregate economic activity. Fiscal deficits and public debt have risen sharply in the wake of the financial crisis.
Jesus Fernandez-Villaverde +3 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Ìнформаційні технології в освіті, 2009 In this article will be examine the architecture and advantages of introduction the module” Laboratory works”, the environment of distant education ”The basics of algoritmization and programming”.
N. Kovalenko
doaj
Directed Search over the Life Cycle [PDF]
We develop a life-cycle model of the labor market in which different worker-firm matches have different quality and the assignment of the right workers to the right firms is time consuming because of search and learning frictions.
Guido Menzio +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Ìнформаційні технології в освіті, 2009 Object of scientific and research job is the branch system of certification of software and information means and databases of scientific and educational purpose of the Ministry of Education and Science of Ukraine.
J.S. Sergeev
doaj
Are Innovation Systems Complex Systems?
, 2016 Basically, complex systems are defined as a large number of autonomous entities in interaction, that create several levels of collective organization leading to emergent (and immergent) behavior. In short, complex systems are characterized by the observation that the whole is more than the sum of the parts (Aristotle).
Muller, Emmanuel +2 more
openaire +3 more sources
Sir Robert Giffen Meets Russia in Early 1990s [PDF]
This paper analyzes the theoretical foundations of Giffen goods and details the difficulty with which prior studies have encountered limited empirical proof of Giffenity.
Janusz Szyrmer, Yochanan Shachmurove
core