Results 141 to 150 of about 28,064,677 (308)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
System level variation analysis of product development
, 2002 Thesis (S.M.)--Massachusetts Institute of Technology, System Design & Management Program, 2002.Includes bibliographical references (leaf 87).by Charles M.
Hura, Charles M. (Charles Michael), 1961-
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Peculiarities of Formation of Innovation Systems and their Characteristics
Управленческое консультирование, 2018 The article describes the special characteristics of innovation systems to obtain a synergistic effect. The reasons for the Russia’s lag in the innovative development are identified; the authors conclude that the state as such has not yet formed an order
Alexei Valeryevich Kulagin +2 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Teacher Retirement System of Texas Laws and Rules [PDF]
, 2014 Laws and rules of the Teacher Retirement System of Texas published as a convenience to interested ...
Teacher Retirement System of Texas
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Hierarchical causal accident analysis of acomplex system
, 2002 Thesis (S.M.)--Massachusetts Institute of Technology, System Design & Management Program, 2002.Includes bibliographical references (leaves 55-57).by David G.
Bancroft, David G. (David Gordon), 1960-
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Strategic system design and development using collaborative tools [PDF]
, 2001 Thesis (S.M.)--Massachusetts Institute of Technology, System Design & Management Program, 2001.Includes bibliographical references (p. 77-80).This thesis focuses on the fields of technology and business in order to enhance and optimize system design ...
Harrigan, Peter A. M. (Peter Arthur Michael), 1964-
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source