Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Teacher Retirement System of Texas (TRS) Laws and Rules
A guide to the laws and rules of the Teacher Retirement System of ...
Teacher Retirement System of Texas
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Robot-Assisted Radical Prostatectomy Using the Hugo RAS System: The First 15 Cases by a First-Year Novice Surgeon Without Prior Console Experiences. [PDF]
Yang CH +7 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Teacher Retirement System of Texas (TRS) Benefits Handbook, December 2013
A guide to benefits of the Teacher Retirement System of ...
Teacher Retirement System of Texas
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Clinical Teaching Fellow Practice Within Complex Clinical-Educational Systems: An Activity Theory-Informed Case Study. [PDF]
Jones N, Khan Z, Watson K.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Texas A&M University System Reports
Annual financial report of the Texas A&M University System documenting income, expenditures, and other relevant financial information for fiscal year ...
Texas A & M University System
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Atomistic insights into the migration and diffusion behavior of crosslinking byproducts in polyethylene networks. [PDF]
Zhao C +8 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source

