Results 161 to 170 of about 40,752,794 (367)
Efficient Learning, Job Turnover and Wage Dispersion [PDF]
This paper studies the aggregate consequences of individual learning in the labor market. Specifically, I examine this issue in a model of directed search on the job.
Fei Li
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Aggregate Uncertainty in the Citizen-Candidate Model Yields Extremist Parties [PDF]
We extend the 'citizen candidate' model of party formation to allow for aggregate uncertainty over the distribution of preferenecs in order to address free entry in some earlier research on electoral competition with aggregate uncertainty with a fixed ...
Jaideep Roy, Sandro Brusco
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
We develop a tractable model of the allocation of ownership and control in firms in competitive markets that permits study of how the scarcity of assets in the market translates into control allocations inside the organization.
Andrew F. Newman, Patrick Legros
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Family Income and Child Outcomes:The 1990 Cocoa Price Shock in Cote d'Ivoire [PDF]
We study the drastic cut of the administered cocoa producer price in 1990 Cote d'Ivoire and investigate the extent to which cocoa producers' children suffered from this severe income shock in terms of school enrollment, increased labor, height stature ...
Denis Cogneau, Remi Jedwab
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source