Results 111 to 120 of about 3,651,049 (265)
System approach and the classification of bibliography functions in document-centrist paradigm
Библиосфера, 2014 The results of developing the document-centrist paradigm in bibliogragraphy are summed up, its main methodological advances are stated, the authors’ point of views are presented and the solution of the problem of the bibliography functions classification
A. V. Sokolov, T. F. Berestova
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
DETERMINATION OF INDUSTRIAL ENTERPRISE MANAGEMENT PRIORITY TASKS AND ASSESSMENT OF ITS CONDITION
Модернизация, инновация, развитие, 2016 This paper presents a new systematic approach to identifying main pyramid projections of business for main consumers of company’s products and services. Pyramid and matrix business concepts are introduced through which the consumers may assess the state ...
A. A. Vartanyan
doaj
Sociotechnical Work System Approach to Occupational Fatigue. [PDF]
Jt Comm J Qual Patient Saf, 2023 Watterson TL +5 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Orthopedics and Traumatology Skill Matrix for Musculoskeletal System Approach by Medical Graduates. [PDF]
Rev Bras Ortop (Sao Paulo), 2023 Siqueira EM, Pereira AA, Oliveira IAKM.
europepmc +1 more source