Results 91 to 100 of about 3,836,313 (269)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimization problems in designing automobiles

Transport, 2008
A mathematical model of optimization problems in designing automobiles is suggested and requirements raised are defined taking into account the main technical and economic characteristics of the automobile.
Ivan Dyakov, Olegas Prentkovskis
doaj  

The BrainHealth Databank: a systems approach to data-driven mental health care and research

Frontiers in Neuroinformatics
IntroductionMental health care is undermined by fragmented data collection, as incomplete datasets can compromise treatment efficacy and research. The BrainHealth Databank (BHDB) at the Centre for Addiction and Mental Health (CAMH) establishes the ...
Jose Arturo Santisteban, David Rotenberg, Stefan Kloiber, Stefan Kloiber, Marta M. Maslej, Marta M. Maslej, Adeel Ansari, Bahar Amani, Darren Courtney, Darren Courtney, Farhat Farrokhi, Natalie Freeman, Masooma Hassan, Lucia Kwan, Mindaugas Mozuraitis, Michael Lau, Natalia Potapova, Farhad Qureshi, Nicole Schoer, Nelson Shen, Nelson Shen, Joanna Yu, Noelle Coombe, Kimberly Hunter, Kimberly Hunter, Kimberly Hunter, Peter Selby, Peter Selby, Nicole Thomson, Nicole Thomson, Damian Jankowicz, Damian Jankowicz, Sean L. Hill, Sean L. Hill   +33 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

METHODOLOGY OF SYSTEM APPROACH TO PLANNING AND PERFORMANCE

Вестник Кемеровского государственного университета, 2014
The paper is devoted to the actual problem of the methodology of system approach to planning in the organization. Results of studying the current practice and theory of planning are reported. The main problems of planning from the point of view of system
O. I. Vashchilova
doaj  

Modelling greenhouse gas emissions from organic and conventional dairy farms

Landbauforschung, 2019
Dairy farming is a major source of greenhouse gas (GHG) emissions in agriculture. There are numerous scientific studies analysing GHG flows and testing GHG reduction methods in dairy farming, yet very few scientific papers cover all the relevant GHG ...
Frank, Helmut, Schmid, Harald, Hülsbergen, Kurt-Jürgen   +2 more
doaj   +1 more source