Results 71 to 80 of about 5,197,383 (319)
Whole System Design: An Integrated Approach to Sustainable Engineering
, 2013 Whole System Design is increasingly being seen as one of the most cost-effective ways to both increase the productivity and reduce the negative environmental impacts of an engineered system.
Stasinopoulos, P +3 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2010 Currently the most frequently used tools for investigating and learning from industrial accidents are based on linear, reductionist models of event causality.
Carhart, NJ, Yearworth, M
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Correction to: Measuring disease activity in COPD: is clinically important deterioration the answer?
Respiratory Research, 2021 Dave Singh +6 more
doaj +1 more source
Открытое образование (Москва), 2018 Modern graduates need to work with electronic devices. On laboratory work, students conduct experiments to solve practical problems of researching real problems that arise in the design and operation of electronic devices.
Oleg V. Stukach, Arman B. Mirmanov
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Co-evolutionary analysis: a policy exploration method for system dynamics models
, 2013 Journal articleIn system dynamics (SD), complex nonlinear systems can generate a wide range of possible behaviours that frequently require search and optimization algorithms in order to explore optimal policies. Within the SD literature, the conventional
Hongliang, Liu +2 more
core +1 more source
A Complexity Analysis Approach for Model-based System Engineering
, 2020 With the increasing complexity of the highly engineered products, Model-based Systems Engineering (MBSE) is proposed to support the complexity management of the product development.
Jinwei Chen +11 more
core +1 more source
METHODS OF EVALUATION AND INDICATORS OF OPTIMAL TEMPERATURE OF INTERNAL COMBUSTION ENGINES AND VEHICLES IN OPERATION [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2015 The results of forming methods of determination and system, as a part of the computer-integrated technology of transport operation, estimation of indecies of the optimal temperature state of the ICE and the vehicle under operation conditions, which is ...
V. Volkov, I. Grytsuk
doaj
METHODOLOGICAL ASPECTS OF IMPROVING CORPORATE REMUNERATION SYSTEMS
Вестник Российского экономического университета имени Г. В. Плеханова, 2019 Today the quality of human potential and its efficient use are becoming extremely important for successful development of organizations. The necessary condition for this is the development and upgrading of flexible and efficient models of personnel ...
Liliya S. Babynina, Tatyana V. Arkadeva
doaj +1 more source