Results 51 to 60 of about 3,836,313 (269)
Sovremennye Issledovaniâ Socialʹnyh Problem, 2015 Статья посвящена рассмотрению важнейшей проблемы современного социально-гуманитарного знания – построения обобщающей социальной теории, способной раскрыть онтологическую природу социальности, дать универсальную теоретико-методологическую парадигму ...
Filipp Ivanovich Rozanov
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Cybernetic model of the regional situation center
Технічна інженеріяThis article discusses the authorʼs approach to solving the problem of structural synthesis of a complex information-analytical management system in the form of a regional situation center.
Yu.B. Brodskyi, S.V. Kovbasiuk
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Управленческое консультирование, 2019 In the article questions of management of social and economic development of territorial subjects of the Russian Federation are considered. It is shown that among problematic and key issues application of a system of strategic planning is found ...
G. Yu. Gagarina, S. N. Miroshnikov
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Sustainable development: interdisciplinary aspects of academic course development
RUDN Journal of Ecology and Life Safety, 2018 Important for the improvement of the course Sustainable development is to familiarize students with the basic principles of the system analysis of interdisciplinary problems, risk analysis methodology and various aspects of the impact of sociocultural ...
Tatiana Vladimirovna Vashchalova
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Pharmacogenomics: a systems approach [PDF]
WIREs Systems Biology and Medicine, 2010 AbstractPharmacogenetics and pharmacogenomics involve the study of the role of inheritance in individual variation in drug response, a phenotype that varies from potentially life‐threatening adverse drug reactions to equally serious lack of therapeutic efficacy.
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source