Results 111 to 120 of about 34,241,884 (316)
Ученые записки Российской академии предпринимательства, 2021 The relevance of the article is the fact that progressive and dynamic socio-economic development of the Russian Federation subjects with a view to ensuring their economic viability requires research and objective solution to the problem of effective ...
A. V. Milenkov
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
ТЕОРЕТИЧЕСКИЕ ОСНОВАНИЯ ЭКОЛОГИЧЕСКОЙ ПОДГОТОВКИ СТУДЕНТОВ ТЕХНИЧЕСКИХ ВУЗОВ
Научно-педагогическое обозрение, 2018 Обсуждаются особенности экологической подготовки студентов российских технических вузов в условиях реформирования системы образования. Инженерно-технический профиль будущего бакалавра обязывает строить эколого-образовательный процесс иначе, чем в случае ...
Филичев Сергей Александрович +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Error propagation of optimal system design in a hierarchical enterprise [PDF]
, 2007 Thesis (S.M.)--Massachusetts Institute of Technology, System Design and Management Program, 2007.Includes bibliographical references (p. 62-63).Increased computing power has helped virtual engineering become common practice amongst product development ...
Lloyd, Jeffrey (Jeffrey M.)
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
TRS Automated Telephone System [PDF]
, 2013 This pamphlet provides helpful instructions to the Teacher Retirement System of Texas' automated telephone ...
Teacher Retirement System of Texas
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source