Results 141 to 150 of about 34,241,884 (316)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
State of Ohio : strategic plan
, 2005 Title from URL of PDF document (viewed Nov. 1, 2005).; "6/20/2005"--P. 1, etc.; Harvested from the web on 11/1/055.3.1.00 general ledger (135 p.) -- 5.3.2.00 accounts payable (77 p.) -- 5.3.3.00 procurement (180 p.) -- 5.3.4.00 grants, project costing ...
Ohio Administrative Knowledge System.
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Application of an engineering and management approach to the incorporation of an information management system at a manufacturing company [PDF]
, 2000 Thesis (S.M.)--Massachusetts Institute of Technology, System Design & Management Program, February 2000.Includes bibliographical references (leaf 56).Sikorsky Aircraft Corporation, a helicopter manufacturing company, is in the process of implementing a ...
Ezzo, Jeffrey P. (Jeffrey Paul), 1957-
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Інформаційні технології і засоби навчання, 2010 In the paper the scientific approaches to modeling of innovation educational environment of a general educational institution – system (analysis of object, process and result of modeling as system objects), activity (organizational and psychological ...
Anzhelika D. Tsymbalaru
doaj
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
System development : an algorithmic approach
, 1987 The subject chosen to develop this thesis project on is developing an algorithm or methodology for system selection. The specific problem studied involves a procedure to determine anion computer system alternative is the best choice for a given user ...
Weingartner, Stephan G.
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