Results 141 to 150 of about 46,188,830 (352)

Software Reliability Estimation of Component-Based Systems

IEEE Access
Component-based software systems (CBSS) have gained significant traction among researchers and practitioners because of their numerous advantages. By assembling software from reusable components, CBSS can reduce time-to-market and maintenance costs while
Ibrahim Ayman Tagen, Khaled T. Wassef, Ramadam Moawad, Sabah Sayed Mohammad   +3 more
doaj   +1 more source

System architecture directions for networked sensors

SIGP, 2000
Jason L. Hill, R. Szewczyk, Alec Woo, S. Hollar, D. Culler, K. Pister   +5 more
semanticscholar   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Sport and Architecture

, 2015
Presented on September 24, 2015 from 11:00 am to 12:00 noon in the Georgia Tech Architecture Library.Dr. Benjamin Flowers is an Associate Professor in the School of Architecture at Georgia Tech.Runtime: 56:01 ...
Flowers, Benjamin
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Architecture of Reconciliation on the Lachine Canal: A Story of Decolonization over Seven Generations

, 2023
This thesis proposes strategies for architecture to redress the impacts of colonization and industrialization that have overshadowed and erased Indigenous narratives from public memory in lands and waters of Tiohtiá:ke (Montreal).
Grant, George
core  

Migration of tools and methodologies for performance prediction and efficient HPC on cloud environments: results and conclusion

Journal of Computer Science and Technology, 2018
Progress in the parallel programming field has allowed scientific applications to be developed with more complexity and accuracy. However, such precision requires greater computational power in order to be executed.
Ronal Muresano, Alvaro Wong, Dolores Rexachs del Rosario, Emilio Luque Fadón   +3 more
doaj  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source