Results 241 to 250 of about 25,813,097 (311)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Meeting Report of the Intergovernmental Panel on Climate Change Expert Meeting on Scenarios [PDF]

, 2016

core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Limits to educational change /

, 1978
The International Movement Towards Educational Change, Dalin, Per   +1 more
core   +1 more source

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Changing systems by changing individuals: the incubation approach to systems change

American Journal of Community Psychology, 2007
AbstractThis article describes and evaluates the implementation of an innovative approach to systems change, the incubation approach, which was developed on a systems change project designed to increase the capacity of multiple systems (e.g., law enforcement, child protection, domestic violence, mental health, early education) to respond to children's ...
Susan L, Staggs, Marlita L, White, Paul A, Schewe, Erica B, Davis, Ebony M, Dill   +4 more
openaire   +2 more sources

System tools for system change

BMJ Quality & Safety, 2011
BackgroundHealth system transformations are influenced by dynamic relationships within and between individuals and institutions, as well as political, educational and legislative factors. This article aims to promote awareness of five tools that recognise this complexity and that are proposed to have value for decision makers: concept mapping, social ...
Willis, C., Mitton, C., Gordon, J., Best, A.   +3 more
openaire   +3 more sources

It's always both: Changing individuals requires changing systems and changing systems requires changing individuals

Behavioral and Brain Sciences, 2023
Abstracts-Frames and i-frames do not represent two opposed types of intervention. Rather they are interpretive lenses for focusing on specific aspects of interventions, all of which include individual and structural dimensions. There is no sense to be made of prioritizing either system change or individual change, because each requires the other.
Alex Madva, Michael Brownstein, Daniel Kelly   +2 more
openaire   +2 more sources